DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp267

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_006232347.1	Gene:	Zfp267 / 100359945	RGDID:	2323100	Length:	796	Species:	Rattus norvegicus

Alignment Length:	648	Identity:	144/648 - (22%)
Similarity:	229/648 - (35%)	Gaps:	166/648 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CRNFSDCRSKRNAAQQQRLG--------------FFRFPKCPDTFKAWLAFCGYTEESLKLKNPC 58
            |..|.:...:.:....|::|              ||..|..|..        ..:.:.|:::  .
  Rat   237 CNQFENSIMENSLVYNQQIGLSCAKAQNSPKYGRFFTHPISPSQ--------NSSTDILEIQ--Y 291

  Fly    59 ICIEHFKDEDIEGSLKFEMGLAKKRTLRPGAVPCVNKSQESGSDRARKERSQRRRNQEL------ 117
            ||.|:.|....|.:|....|:....|:..|        .|:.||.|.:......::..|
  Rat   292 ICKENRKGFAEESTLSNRQGMYIAETVYQG--------NENNSDLALESYPANHQSAHLYKCYKC 348

  Fly   118 ------VAELLAEEEAKLIHPE---------ATSFEQDSVYLSETVTMELDPLSGEEKLEELQKC 167
                  .:||:..:   .||.:         :|:|.|.|            .|:.....|:..||
  Rat   349 DTAFHQYSELIIHQ---YIHIQDQISKGMDCSTAFHQSS------------SLTKSHAGEKPYKC 398

  Fly   168 RTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMCI 232
            :.|...||           ..|.|..|..:.||| ..||       |..|..|      |....:
  Rat   399 KECGKAFT-----------YCSSLRQHHRIHSGV-KQHK-------CKDCGKA------FYHKSL 438

  Fly   233 STELKLSQA--KPSTDEVQIEAENENPISSDHDLISDTENTNVEEIEDAGGDHVEDEATSDDQTS 295
            .|:.:...|  ||...:...:|.|:....:.|..|...|...          |.:|...:..|.|
  Rat   439 LTQHQSIHAGKKPYCCKFCGKAFNQRSTVTQHQRIHTGERPY----------HCKDCGKAFHQRS 493

  Fly   296 QEAVDEVAESPAAQDPLSVALGAKIF--KELLDQ----YTGKEKARLRKGAPIASKPKAKEKAAG 354
            ..::.:...:  .:.|.......|.|  ..||.|    :||:.....              |..|
  Rat   494 SLSLHQRVHT--GEKPYKCKECGKAFNRNSLLTQHQRIHTGERPYHC--------------KDCG 542

  Fly   355 EQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECP 419
            :...|:|         :|.:..::......:.|..||:||....:|.:|...||..|..:|.||.
  Rat   543 KTFNKKS---------SLTQHQRIHTGEKPYSCKDCGKAFNQRSSLSLHQRGHTGEKPNKCNECG 598

  Fly   420 KTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKP 484
            |.|...:....|.:| |.||..:.|..|.:.|....:..:|: .||..              .||
  Rat   599 KAFNRVFFLTQHQKI-HTGEKAYHCKDCGKAFKQRSSLTQHQ-RVHTG--------------DKP 647

  Fly   485 RESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCD 548
                 |.||.|.|.:..:.:...|.:.||....||||.|.|::|....|.:|:..|. ::|..|.
  Rat   648 -----YHCKHCGKAFTQRSSFTRHQRIHTGEKPYKCQDCDKAFSRNLLLIQHQRIHTGEKPYHCQ 707

  Fly   549 VCLKGFYQRTRLREHELIHTGERPYWCEVCNVNF--RYKYN--MKSHANSKMHQ----DNARK 603
            .|.:.|.||:.|.:|:.:|||::|:.|:.|...|  |..:|  .:.|...|.::    |.|.|
  Rat   708 DCGRAFNQRSSLTQHQRVHTGDKPFCCKDCGKAFTQRSSFNRHQRVHTGEKQYKCKECDRAFK 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	18/101 (18%)
		zf-AD	167..240	CDD:214871	17/72 (24%)
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	7/26 (27%)
		C2H2 Zn finger	575..591	CDD:275368	5/19 (26%)
Zfp267	XP_006232347.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	345..364	CDD:275368	2/21 (10%)
		C2H2 Zn finger	375..390	CDD:275368	5/26 (19%)
		C2H2 Zn finger	398..418	CDD:275368	7/30 (23%)
		zf-H2C2_2	410..433	CDD:290200	10/36 (28%)
		C2H2 Zn finger	426..446	CDD:275368	5/25 (20%)
		C2H2 Zn finger	454..474	CDD:275368	3/19 (16%)
		zf-H2C2_2	469..491	CDD:290200	5/31 (16%)
		COG5048	<479..633	CDD:227381	40/189 (21%)
		C2H2 Zn finger	482..502	CDD:275368	3/19 (16%)
		zf-H2C2_2	494..519	CDD:290200	3/26 (12%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		zf-H2C2_2	523..546	CDD:290200	6/36 (17%)
		C2H2 Zn finger	538..558	CDD:275368	5/42 (12%)
		zf-H2C2_2	550..575	CDD:290200	6/24 (25%)
		C2H2 Zn finger	566..586	CDD:275368	7/19 (37%)
		C2H2 Zn finger	594..614	CDD:275368	7/20 (35%)
		zf-H2C2_2	607..631	CDD:290200	8/24 (33%)
		C2H2 Zn finger	622..642	CDD:275368	4/20 (20%)
		zf-H2C2_2	634..659	CDD:290200	10/44 (23%)
		COG5048	645..>699	CDD:227381	19/58 (33%)
		C2H2 Zn finger	650..670	CDD:275368	5/19 (26%)
		zf-H2C2_2	662..687	CDD:290200	9/24 (38%)
		C2H2 Zn finger	678..698	CDD:275368	7/19 (37%)
		zf-H2C2_2	691..715	CDD:290200	7/23 (30%)
		C2H2 Zn finger	706..726	CDD:275368	7/19 (37%)
		zf-H2C2_2	718..743	CDD:290200	9/24 (38%)
		C2H2 Zn finger	734..754	CDD:275368	5/19 (26%)
		zf-H2C2_2	746..771	CDD:290200	6/25 (24%)
		C2H2 Zn finger	762..779	CDD:275368	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100