DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6689 and ZNF729

DIOPT Version :10

Sequence 1:NP_650051.1 Gene:CG6689 / 41345 FlyBaseID:FBgn0037877 Length:613 Species:Drosophila melanogaster
Sequence 2:NP_001229609.1 Gene:ZNF729 / 100287226 HGNCID:32464 Length:1252 Species:Homo sapiens


Alignment Length:593 Identity:139/593 - (23%)
Similarity:219/593 - (36%) Gaps:147/593 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 RCAVPNCRNFSDCRSKRNAAQQQRLGFFRFPKCPDTFKAWLAFCGYTEESLKLKNPCICIEHFKD 66
            ||...|.|...||:| .|..:..:.|:.:..:|            .|....|:..   |.:|.|.
Human   114 RCGHKNLRLRKDCKS-ANEGKMHKEGYNKLNQC------------RTATQRKIFQ---CNKHMKV 162

  Fly    67 EDIEGSLKFEMGLAKKRTLRPGAVPCVNKSQESGSDRARKERSQRRRNQELVAELLAEEEAKLIH 131
            .. :.|.:.::...||:|.:  .:.| :||....|...|.:|...|:|     ....||..|   
Human   163 FH-KYSNRNKVRHTKKKTFK--CIKC-SKSFFMLSCLIRHKRIHIRQN-----IYKCEERGK--- 215

  Fly   132 PEATSFEQDSVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIE 196
                :|:..|......:      :..|:|..:.:||...:. |::.|..             |..
Human   216 ----AFKSFSTLTKHKI------IHTEDKPYKYKKCGNAFK-FSSTFTK-------------HKR 256

  Fly   197 VISGVWISHKPDEPRLMCPACKSALDQAIDFREMCISTELKLSQAKPSTDEVQIEAENENPISSD 261
            :.:|        |....|..|..|.:|:.:.                                :|
Human   257 IHTG--------ETPFRCEECGKAFNQSSNL--------------------------------TD 281

  Fly   262 HDLISDTENTNVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLD 326
            |..|...|.|  .:.|:.|     .........:...|...||.|...:..     .|.|...  
Human   282 HKRIHTGEKT--YKCEECG-----KAFKGSSNFNAHKVIHTAEKPYKCEDC-----GKTFNHF-- 332

  Fly   327 QYTGKEKARLRKGAPI--ASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQ 389
                   :.|||...|  ..||..:|:..     |..:...|..:..:|...:   ||  :.|::
Human   333 -------SALRKHKIIHTGKKPYKREECG-----KAFSQSSTLRKHEIIHTGE---KP--YKCEE 380

  Fly   390 CGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYP 454
            ||:||:.|..|.:|.:.||..|.|:|.||.|.|........| :|.|.|:.|:.|..|.:.|...
Human   381 CGKAFKWSSKLTVHKVVHTGEKPYKCEECGKAFSQFSTLKKH-KIIHTGKKPYKCEECGKAFNSS 444

  Fly   455 GARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYK 519
            ....||:. :|..              .||     |:|:.|.|.:.....|..|...||....||
Human   445 STLMKHKI-IHTG--------------EKP-----YKCEECGKAFRQSSHLTRHKAIHTGEKPYK 489

  Fly   520 CQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFR 583
            |:.|.|:::..:.|:||::.|. |:|.:|:.|.|.|.|.:.||.|::|||||:||.||.|...|:
Human   490 CEECGKAFNHFSDLRRHKIIHTGKKPYKCEECGKAFSQSSTLRNHQIIHTGEKPYKCEECGKAFK 554

  Fly   584 YKYNMKSH 591
            :...:..|
Human   555 WSSKLTVH 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6689NP_650051.1 THAP 2..94 CDD:214951 20/91 (22%)
zf-AD 166..241 CDD:462262 11/74 (15%)
zf-C2H2 385..407 CDD:395048 8/21 (38%)
C2H2 Zn finger 387..407 CDD:275368 8/19 (42%)
C2H2 Zn finger 415..436 CDD:275368 7/20 (35%)
C2H2 Zn finger 444..460 CDD:275368 3/15 (20%)
C2H2 Zn finger 492..512 CDD:275368 5/19 (26%)
C2H2 Zn finger 520..540 CDD:275368 6/19 (32%)
C2H2 Zn finger 547..567 CDD:275368 8/19 (42%)
zf-met 573..597 CDD:463736 6/19 (32%)
C2H2 Zn finger 575..591 CDD:275368 4/15 (27%)
ZNF729NP_001229609.1 KRAB 13..73 CDD:214630
C2H2 Zn finger 182..202 CDD:275368 6/20 (30%)
C2H2 Zn finger 210..230 CDD:275368 5/32 (16%)
C2H2 Zn finger 239..258 CDD:275368 5/32 (16%)
COG5048 262..666 CDD:227381 98/385 (25%)
C2H2 Zn finger 266..286 CDD:275368 6/51 (12%)
C2H2 Zn finger 294..314 CDD:275368 3/24 (13%)
C2H2 Zn finger 322..342 CDD:275368 5/33 (15%)
C2H2 Zn finger 351..370 CDD:275368 3/23 (13%)
C2H2 Zn finger 378..398 CDD:275368 8/19 (42%)
C2H2 Zn finger 406..426 CDD:275368 7/20 (35%)
C2H2 Zn finger 434..454 CDD:275368 5/20 (25%)
C2H2 Zn finger 462..482 CDD:275368 5/19 (26%)
C2H2 Zn finger 490..510 CDD:275368 6/19 (32%)
C2H2 Zn finger 518..538 CDD:275368 8/19 (42%)
C2H2 Zn finger 546..566 CDD:275368 5/17 (29%)
C2H2 Zn finger 574..594 CDD:275368
C2H2 Zn finger 602..622 CDD:275368
COG5048 625..1123 CDD:227381
C2H2 Zn finger 630..650 CDD:275368
C2H2 Zn finger 658..678 CDD:275368
C2H2 Zn finger 686..706 CDD:275368
C2H2 Zn finger 714..734 CDD:275368
C2H2 Zn finger 742..762 CDD:275368
C2H2 Zn finger 770..790 CDD:275368
C2H2 Zn finger 798..818 CDD:275368
C2H2 Zn finger 826..846 CDD:275368
C2H2 Zn finger 854..874 CDD:275368
C2H2 Zn finger 882..902 CDD:275368
C2H2 Zn finger 910..930 CDD:275368
C2H2 Zn finger 938..958 CDD:275368
C2H2 Zn finger 966..986 CDD:275368
C2H2 Zn finger 994..1014 CDD:275368
C2H2 Zn finger 1022..1042 CDD:275368
C2H2 Zn finger 1050..1070 CDD:275368
C2H2 Zn finger 1078..1098 CDD:275368
C2H2 Zn finger 1106..1126 CDD:275368
zf-H2C2_2 1119..1143 CDD:463886
C2H2 Zn finger 1134..1154 CDD:275368
C2H2 Zn finger 1162..1182 CDD:275368
zf-H2C2_2 1174..1199 CDD:463886
C2H2 Zn finger 1190..1210 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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