DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Gm14124

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001135882.1	Gene:	Gm14124 / 100216455	MGIID:	3652002	Length:	715	Species:	Mus musculus

Alignment Length:	639	Identity:	153/639 - (23%)
Similarity:	222/639 - (34%)	Gaps:	163/639 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KCPDTFKAWLAFCG-------YTEESLKLKNPCICIEHFKDEDIEGSLKFEMGLAKKRTLRPGAV 90
            ||....||:....|       :|||.|...|.|       |:...|    :.||...:....|..
Mouse   160 KCNQCGKAFACSTGLRGHKRTHTEEKLNECNQC-------DKAFAG----QSGLLYHKRTHTGEK 213

  Fly    91 PCVNKSQESGSDRARKE---RSQRRRNQELVAELLAEEEAKLIH--------------P-EATSF 137
            |.  :..:.|...||..   :.:|....|...|....|:|.:.|              | |....
Mouse   214 PF--QCNQCGKTFARNTHLLQHKRVHTGEKPYECNQCEKASVCHIGLLYHKRTHAGQRPYECNEC 276

  Fly   138 EQDSVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFT-------------------ADFRAKDL 183
            .:..||.| .:.......:||:..|    |..|...|.                   .|...||.
Mouse   277 GKSIVYHS-CIKQCKRRHTGEKPFE----CNQCGKSFARKSHLLRHKRIHTGEKPYKCDQCGKDF 336

  Fly   184 FDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMCISTELKLSQAKPSTDEV 248
            ..|  |.|.:|..|.:|    .||.|    |..|..|         ...||.|: ...:..|.|.
Mouse   337 ARP--SSLQYHKRVHTG----EKPYE----CKQCGKA---------FACSTVLR-RHKRAHTGEK 381

  Fly   249 QIEAE--NENPISSDHDLISDTENTNVE--EIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQ 309
            ..|..  .::..|..|.|.....:|..:  :.:..|.|.|          ....:.:.....|.:
Mouse   382 PFECYQCGKSFASKSHLLRHKRIHTGEKPYKCDQCGKDFV----------YHSCIKQCKRRHAGE 436

  Fly   310 DPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIR 374
            .|.......|.|..  ..|..:.| |:..|         ::....:|..|..|:..:.:..   :
Mouse   437 KPFECNQCGKSFAS--KSYLLRHK-RIHTG---------EKHYKCDQCGKDFASTYSLQNH---K 486

  Fly   375 RAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGE 439
            |.....||  :.|.|||:||..|..||.|...||..|.::|.:|.|:|........|.|| |.||
Mouse   487 RVHTGEKP--YECKQCGKAFACSSKLRSHKRTHTGEKPFECNQCGKSFAIKSHLLRHKRI-HTGE 548

  Fly   440 TPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYA 504
            .|:.|..|.:.||.|.:.|.|             ||::....|       |:||.|.|.:|....
Mouse   549 KPYKCDQCGKDFARPSSLQYH-------------KRVHTGEKP-------YECKQCGKAFACSRR 593

  Fly   505 LGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE---------------------------- 541
            |..|.::||....|:|.:|.|::|.|:....|:.||.
Mouse   594 LRIHKRTHTGEKPYECNQCGKAFSSPSGFLYHKRTHTGERPYECNECGKSFIHRSNFQMHKRTHT 658

  Fly   542 -KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANS 594
             ::|.:||.|.|.|.|.|.|.:|:.:||||:||.|:.|...|.|...::.|..:
Mouse   659 GEKPFECDQCGKSFAQNTYLLQHKRVHTGEKPYECKHCGKAFAYSNKLRVHVRT 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	17/69 (25%)
		zf-AD	167..240	CDD:214871	21/91 (23%)
		zf-C2H2	385..407	CDD:278523	10/21 (48%)
		C2H2 Zn finger	387..407	CDD:275368	10/19 (53%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	6/15 (40%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	9/19 (47%)
		zf-met	574..597	CDD:289631	5/21 (24%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Gm14124	NP_001135882.1	KRAB	4..>45	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	79..97	CDD:275368
		COG5048	87..514	CDD:227381	88/418 (21%)
		C2H2 Zn finger	105..125	CDD:275368
		zf-H2C2_2	117..142	CDD:290200
		C2H2 Zn finger	133..153	CDD:275368
		C2H2 Zn finger	161..181	CDD:275368	4/19 (21%)
		C2H2 Zn finger	189..209	CDD:275368	6/30 (20%)
		zf-H2C2_2	202..226	CDD:290200	4/25 (16%)
		C2H2 Zn finger	217..237	CDD:275368	4/19 (21%)
		C2H2 Zn finger	245..265	CDD:275368	3/19 (16%)
		C2H2 Zn finger	273..293	CDD:275368	3/20 (15%)
		C2H2 Zn finger	301..321	CDD:275368	3/19 (16%)
		zf-H2C2_2	313..338	CDD:290200	3/24 (13%)
		C2H2 Zn finger	329..349	CDD:275368	7/21 (33%)
		zf-H2C2_2	341..366	CDD:290200	10/41 (24%)
		C2H2 Zn finger	357..377	CDD:275368	6/29 (21%)
		zf-H2C2_2	370..394	CDD:290200	4/24 (17%)
		C2H2 Zn finger	385..405	CDD:275368	3/19 (16%)
		zf-H2C2_2	397..422	CDD:290200	6/34 (18%)
		C2H2 Zn finger	413..433	CDD:275368	3/29 (10%)
		C2H2 Zn finger	441..461	CDD:275368	5/22 (23%)
		zf-H2C2_2	453..478	CDD:290200	6/34 (18%)
		C2H2 Zn finger	469..489	CDD:275368	4/22 (18%)
		zf-H2C2_2	481..506	CDD:290200	9/29 (31%)
		C2H2 Zn finger	497..517	CDD:275368	10/19 (53%)
		zf-H2C2_2	510..533	CDD:290200	9/22 (41%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
		zf-H2C2_2	537..562	CDD:290200	10/25 (40%)
		C2H2 Zn finger	553..573	CDD:275368	9/32 (28%)
		zf-H2C2_2	565..590	CDD:290200	10/44 (23%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
		zf-H2C2_2	594..618	CDD:290200	8/23 (35%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		C2H2 Zn finger	637..657	CDD:275368	0/19 (0%)
		zf-H2C2_2	649..674	CDD:290200	6/24 (25%)
		C2H2 Zn finger	665..685	CDD:275368	9/19 (47%)
		zf-H2C2_2	677..702	CDD:290200	11/24 (46%)
		C2H2 Zn finger	693..713	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100