DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and ZNF717

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	535	Identity:	132/535 - (24%)
Similarity:	190/535 - (35%)	Gaps:	130/535 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SDRARKERSQRRRNQELVAELLAEEEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLEELQ 165
            |.|..:..:|..:.|.|:......|:.|..:.||..|....|::.:|.          .|..|.:
Human   223 SHRHHEHLTQHHKIQTLLQTFQCNEQGKTFNTEAMFFIHKRVHIVQTF----------GKYNEYE 277

  Fly   166 K-CR---------------TC--YNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRL 212
            | |.               ||  .:|||.                 |.:..:|    .||.|
Human   278 KACNNSAVIVQVITQVGQPTCCRKSDFTK-----------------HQQTHTG----EKPYE--- 318

  Fly   213 MCPACKSALDQAIDFREMC-ISTE---------LKLSQAKPSTDEVQIEAENENPISSDH----- 262
             |..|:.......|....| :.||         .||...|.|....|.....|.|...:.
Human   319 -CVECEKPSISKSDLMLQCKMPTEEKPYACNWCEKLFSYKSSLIIHQRIHTGEKPYGCNECGKTF 382

  Fly   263 ---DLISDTENTNVEE-----IEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPLSVALGAK 319
               ..::..|.|:..:     ||.....|.:...|...:|.           :.:.|...:...|
Human   383 RRKSFLTLHERTHTGDKPYKCIECGKTFHCKSLLTLHHRTH-----------SGEKPYQCSECGK 436

  Fly   320 IFKELLDQYTGKEKARLRKGAPIASKPKAKE--KAAGEQKPKRSANPKTKEERNLIRRAQLRAKP 382
            .|.:       |....:........||.|.:  :.|...|.:.:.:          :|.....||
Human   437 TFSQ-------KSYLTIHHRTHTGEKPYACDHCEEAFSHKSRLTVH----------QRTHTGEKP 484

  Fly   383 PNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFC 447
              :.|::||:.|....|||:|...||..|.|:|.||.|||:......:| :..|.||.|:.|..|
Human   485 --YECNECGKPFINKSNLRLHQRTHTGEKPYECNECGKTFHRKSFLTIH-QWTHTGEKPYECNEC 546

  Fly   448 SETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSH 512
            .:||     |.|....||...      ....||         |.|..|.|.|:.|..|..|.::|
Human   547 GKTF-----RCKSFLTVHQRT------HAGEKP---------YACNECGKTYSHKSYLTVHHRTH 591

  Fly   513 TDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCE 576
            |....|:|..|.||:...:.|..|:.||. |:|.:|:.|.|.|..:..|..|:..|||||||.|.
Human   592 TGEKPYECNECGKSFHCKSFLTIHQRTHAGKKPYECNECEKTFINKLNLGIHKRTHTGERPYECN 656

  Fly   577 VCNVNFRYKYNMKSH 591
            .|...||.|.|:.:|
Human   657 ECGKTFRQKSNLSTH 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	19/99 (19%)
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	12/22 (55%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	5/15 (33%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	7/18 (39%)
		C2H2 Zn finger	575..591	CDD:275368	6/15 (40%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630
		KRAB	56..95	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368	3/13 (23%)
		COG5048	343..723	CDD:227381	100/380 (26%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	1/19 (5%)
		zf-H2C2_2	388..412	CDD:290200	4/23 (17%)
		C2H2 Zn finger	403..423	CDD:275368	4/19 (21%)
		zf-H2C2_2	416..440	CDD:290200	5/34 (15%)
		zf-C2H2	429..451	CDD:278523	3/28 (11%)
		C2H2 Zn finger	431..451	CDD:275368	3/26 (12%)
		zf-H2C2_2	443..468	CDD:290200	4/24 (17%)
		C2H2 Zn finger	459..479	CDD:275368	3/29 (10%)
		zf-H2C2_2	472..494	CDD:290200	6/33 (18%)
		C2H2 Zn finger	487..507	CDD:275368	8/19 (42%)
		zf-H2C2_2	499..524	CDD:290200	14/24 (58%)
		C2H2 Zn finger	515..535	CDD:275368	7/20 (35%)
		zf-H2C2_2	528..552	CDD:290200	9/29 (31%)
		C2H2 Zn finger	543..563	CDD:275368	8/30 (27%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		zf-H2C2_2	583..608	CDD:290200	9/24 (38%)
		COG5048	595..932	CDD:227381	31/77 (40%)
		C2H2 Zn finger	599..619	CDD:275368	6/19 (32%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		zf-H2C2_2	639..664	CDD:290200	12/24 (50%)
		C2H2 Zn finger	655..675	CDD:275368	7/17 (41%)
		zf-H2C2_2	667..692	CDD:290200	2/5 (40%)
		C2H2 Zn finger	683..703	CDD:275368
		zf-H2C2_2	779..801	CDD:290200
		C2H2 Zn finger	794..814	CDD:275368
		C2H2 Zn finger	822..842	CDD:275368
		zf-H2C2_2	835..859	CDD:290200
		C2H2 Zn finger	850..870	CDD:275368
		zf-H2C2_2	863..887	CDD:290200
		C2H2 Zn finger	878..898	CDD:275368
		zf-H2C2_2	891..913	CDD:290200
		zf-C2H2	904..926	CDD:278523
		C2H2 Zn finger	906..926	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100