DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4820 and CG8159

DIOPT Version :9

Sequence 1:	NP_001097748.1	Gene:	CG4820 / 41344	FlyBaseID:	FBgn0037876	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	91/366 - (24%)
Similarity:	151/366 - (41%)	Gaps:	55/366 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKEFCRTCGKTVVADECLQIFTPAGRKLLQCVRSITNCWLQNVQDLPNHICTDCQVLLSQVQKFR 65
            ::..||.|..:....:.|::|.....|:||.:..:|...||....||:.:|..||..|.....||
  Fly     2 LQNVCRVCASSTDNSKSLKLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFR 66

  Fly    66 RRCAKIEKYFARRRRRMNLGEAPAAMEQLRVQQAAAPDPLGIDELMSASDIKIEPIQLQMEEDPQ 130
            .||.:.:|.|                |:..|:..        ::...:|..:....|.|..||..
  Fly    67 DRCLRSQKIF----------------EESLVRNE--------EDTFRSSVRRSARSQRQRHEDTA 107

  Fly   131 APYPENQLE-----QALSYGNAPGEDILPLPEDYGEAQTEVATTTNEPAQRRSKNTAKIKSKKHT 190
            ...|.:.||     ::||.|:...:.|..| :...||..|:|......:......|:.::.|: |
  Fly   108 PKTPASPLEVMIKLESLSNGDEEDDGIDHL-DSCNEADMELAIKAMSSSTEDDGTTSPVRLKR-T 170

  Fly   191 MRVGRKLIHVKVIDDKQPKRIVDRNGPSAKPCICEHCGRQFKDTSNLHVHLLRHTGTKPFECDQC 255
            .|.|.          |:..:..:|...:.....|:.||......|:...||.:|:|.:||:|:.|
  Fly   171 RRRGL----------KKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELC 225

  Fly   256 HQKCYTLHLLRRHQLKHT-EGPYACTFCGLEYSTNSSRVRHERE-------ACKK-GRAPQSKW- 310
            ..:..:...|:.||:.|| :..:.|.:|...|...|.|:||||.       .|.: |::..:.:
  Fly   226 PARFLSSGELKGHQVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYI 290

  Fly   311 ----EIIKKGERTFHCEVCDLWFLRAGNFTQHINSSSHIEN 347
                .:|..|||.|.||:|...|.|..:...|..|::|..|
  Fly   291 LKNHMLIHTGERLFRCELCHRSFARPTHLKTHFRSNTHKHN 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4820	NP_001097748.1	zf-AD	4..75	CDD:285071	22/70 (31%)
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..297	CDD:275368	7/17 (41%)
		C2H2 Zn finger	322..339	CDD:275368	5/16 (31%)
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	23/88 (26%)
		C2H2 Zn finger	194..214	CDD:275368	6/19 (32%)
		COG5048	<197..322	CDD:227381	37/124 (30%)
		zf-H2C2_2	206..231	CDD:290200	8/24 (33%)
		C2H2 Zn finger	222..242	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		zf-H2C2_2	265..287	CDD:290200	6/21 (29%)
		C2H2 Zn finger	278..298	CDD:275368	2/19 (11%)
		zf-H2C2_2	291..315	CDD:290200	9/23 (39%)
		C2H2 Zn finger	306..328	CDD:275368	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860