DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4820 and znf281a

DIOPT Version :9

Sequence 1:	NP_001097748.1	Gene:	CG4820 / 41344	FlyBaseID:	FBgn0037876	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_001922388.3	Gene:	znf281a / 100005963	ZFINID:	ZDB-GENE-131126-34	Length:	849	Species:	Danio rerio

Alignment Length:	324	Identity:	69/324 - (21%)
Similarity:	110/324 - (33%)	Gaps:	119/324 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 IDELMSASDIKIEPIQLQMEEDPQAP-YP----------------------ENQLEQALSYGNAP 148
            :.:.:.|..||.|.:.   |.|.:.| ||                      :|.:...||.||..
Zfish    91 VGDYVHAMGIKQEKVS---EHDYRLPLYPGTGTGAGVRSGGELLEVSLGNHQNLVVHDLSLGNLS 152

  Fly   149 GEDILPLPEDYGEAQTEVATTTNEPAQRRSKNTAKIKSKKHTMRVGRKLIHVKVIDDKQPKRIVD 213
            |..:   .|..|...........|...||.:..:|                         ..::|
Zfish   153 GRLV---KESSGRKGRRSNGEGQEAKTRRKRGESK-------------------------SMMLD 189

  Fly   214 RNG----PSAKPCICEHCGRQFKDTSNLHVHLLRHTGTKPFECDQCHQKCYTLHLLRRHQLKHT- 273
            .:|    |::||.|||||...|:.:.:|..|:|.|||.:||.|.||:......:||:||:..|:
Zfish   190 PDGGSLSPNSKPHICEHCNAAFRSSYHLRRHVLIHTGERPFRCTQCNMSFIQKYLLQRHEKIHSG 254

  Fly   274 EGPYACTFCGLEYSTNSSRVRHEREACKKGRAPQSKWEIIKKGERTFHCEVCDLWFLRAGNFTQH 338
            |.|::|..|.:.:.......||:|               ...||:.:.|:.|..:|.|.....:|
Zfish   255 EKPFSCDQCNMRFIQKYHMERHKR---------------THSGEKPYKCDTCQQYFSRTDRLLKH 304

  Fly   339 ------------------INSSSHIEN---------------------------ERRKKRKSNP 357
                              :.|:...|:                           ||::|:.|.|
Zfish   305 KRTCGDAIKKGLDGADHELGSAGDTEHGSYGISQGNTPTPARKRGKSKTPGEGGERKRKKASGP 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4820	NP_001097748.1	zf-AD	4..75	CDD:285071
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..297	CDD:275368	4/17 (24%)
		C2H2 Zn finger	322..339	CDD:275368	5/34 (15%)
znf281a	XP_001922388.3	COG5048	<194..>292	CDD:227381	35/112 (31%)
		zf-C2H2	202..224	CDD:278523	9/21 (43%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		zf-H2C2_2	216..241	CDD:290200	11/24 (46%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		zf-H2C2_2	245..269	CDD:290200	8/23 (35%)
		C2H2 Zn finger	260..280	CDD:275368	5/34 (15%)
		zf-H2C2_2	272..297	CDD:290200	8/39 (21%)
		C2H2 Zn finger	288..307	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910