DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and Slc30a7

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_075703.1	Gene:	Slc30a7 / 66500	MGIID:	1913750	Length:	378	Species:	Mus musculus

Alignment Length:	380	Identity:	233/380 - (61%)
Similarity:	284/380 - (74%)	Gaps:	20/380 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIPLSHKD--RSSLGYRIREKLNSWKRLIFSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLI 63
            |:|||.||  .....:.:..|::.|.|.|.||:.|||||.||.||||||||||.|||.:|.||||
Mouse     1 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLI 65

  Fly    64 SDSFHMFFDCTGLLAGLAASVITKWKANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERL 128
            |||||||||.|.:|||||||||:||:.||.||||||||||||||||.|||:|.||||.||||||.
Mouse    66 SDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERA 130

  Fly   129 IEPPEVKHERLFVVSVLGLLVNLVGIYAFNHGGHGHSHG-GHGHSHGGGHGH-GHSHGHTDAGNH 191
            :.||:|.||||.:||:||.:||||||:.||||||||||| ||||||...:|. .|||||.| ..|
Mouse   131 LAPPDVHHERLLLVSILGFVVNLVGIFVFNHGGHGHSHGSGHGHSHSLFNGALDHSHGHED-HCH 194

  Fly   192 NHQAITLDNGHGHSHDHDSHGHSHGDM-----------SGSNSQIMRGVFLHILADTLGSVGVII 245
            :|:|   .:|..|||||| |.|.||.:           :|.:.||::|||||||||||||:|||.
Mouse   195 SHEA---KHGAAHSHDHD-HAHGHGHLHSHDGPSFKATAGPSRQILQGVFLHILADTLGSIGVIA 255

  Fly   246 SAVLMHMFGWMIADPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGV 310
            ||::|..||.|||||||||.||:||.:||:.|::||:.|||||.|..|:.:||||||:|..|.||
Mouse   256 SAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPSLENTLPQCYQRVQQLQGV 320

  Fly   311 YAVQEPHFWTLCSDVYVGALKLEVSKNVDPKYVVTHTRMIFEAVGVKQIYIQLDY 365
            |.:||.||||||||||||.|||.|:.:.|.:::::.|..||...||:|:|:|:|:
Mouse   321 YNLQEQHFWTLCSDVYVGTLKLVVAPDADARWILSQTHNIFTQAGVRQLYVQIDF 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	210/333 (63%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	165/252 (65%)
Slc30a7	NP_075703.1	CzcD	31..376	CDD:224151	223/350 (64%)
		Cation_efflux	48..296	CDD:279834	165/252 (65%)
		His-rich loop	161..220		36/63 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..224		19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848160
Domainoid	1	1.000	336	1.000	Domainoid score	I1120
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11332
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1582
Isobase	1	0.950	-	0	Normalized mean entropy	S2410
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D1507860at2759
OrthoFinder	1	1.000	-	-		FOG0002128
OrthoInspector	1	1.000	-	-		oto92503
orthoMCL	1	0.900	-	-		OOG6_106189
Panther	1	1.100	-	-	LDO	PTHR45755
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1409
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750