Protein Alignment ZnT86D and SLC30A10

DIOPT Version :9

• Sequence 1: NP_650049.1
• Gene: ZnT86D / 41342
• FlyBaseID: FBgn0037875
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_061183.2
• Gene: SLC30A10 / 55532
• HGNCID: 25355
• Length: 485
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 112/387 - (28%)
• Similarity: 175/387 - (45%)
• Gaps: 53/387 - (13%)

  Fly    28 FSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLISDSFHMFFDCTGLLAGLAASVITKWKAND 92
            :|.:..|.||: |:|.::|...||..|.:.||:.|:||||:|..|...|..||:|..|.: :...
Human     4 YSGKTCRLLFM-LVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIAR-RPTR 66

  Fly    93 KFS--YGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPPEVKH-ERLFVVSVLGLLVNLVGI 154
            .||  |||.||||:....|::||..:.|.|..|.|.||..|..:.. |.:.:|.|||||||:||:
Human    67 GFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGL 131

  Fly   155 YAFNHGG-------HGHS----------HGGHGHSHGGGHGHGHSHGHTD-AGNHNHQAITLDNG 201
            ..|....       .|.|          .|....:.||..|........| ....:..|:|| .|
Human   132 LIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTL-RG 195

  Fly   202 HGHSHDHDSHGHSHGDMSG------------------SNSQIMRGVFLHILADTLGSVGVIISAV 248
            .......:.......:::|                  |.:..:|||.||::.|.||||.|:|:|:
Human   196 TSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAI 260

  Fly   249 LMHMF--------GWM-IADPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQKV 304
            :.::.        .|. ..||..::.:.::|..|...||||:..||:|..|..:  ::.:...|:
Human   261 IFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGV--NMEELMSKL 323

  Fly   305 TGLAGVYAVQEPHFWTLCSDVYVGALKLEVSKNVDPKYVVTHTRMIFEAVGVKQIYIQLDYV 366
            :.:.|:.:|.|.|.|.|.|...:..|.::..|:...:...|..|.||...|:..:.||.:.|
Human   324 SAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENV 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	105/367 (29%)
		Cation_efflux	46..286	CDD:279834	85/287 (30%)
SLC30A10	NP_061183.2	CzcD	10..383	CDD:224151	110/377 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..196		7/29 (24%)
		Required for plasma membrane localization. /evidence=ECO:0000269|PubMed:25319704	308..485		20/80 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850