DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and slc30a1

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001007940.1	Gene:	slc30a1 / 493316	XenbaseID:	XB-GENE-484357	Length:	493	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	124/413 - (30%)
Similarity:	189/413 - (45%)	Gaps:	82/413 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NSRNLFLFLL-LNLSFAFVELFYGIVTNSLGLISDSFHMFFDCTGLLAGL-AASVITKWKANDKF 94
            :||...||:| |...|..||:....||.||.::||||||..|...|:.|| |.....|.::.||.
Frog     4 SSRVRLLFMLALTFIFFVVEVVVSRVTGSLAMLSDSFHMLSDVIALVVGLVAVRFAQKTRSTDKN 68

  Fly    95 SYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPPEVKHERLFV-VSVLGLLVNLVGIYAF- 157
            ::|::||.|:...||::||..:.|.|:.|.:||..||..::...:.: |...|||:||:|:..|
Frog    69 TFGWIRAGVMGALVNAVFLTALCFTIVLEAIERFTEPQAIEQPLVVMGVGAGGLLINLIGLCMFR 133

  Fly   158 NHGGHGHSHGGHGHSHGGGHGH---GHSHGHTDAGNHNHQAITLDN---------GHGHSHDHDS 210
            :..||||||||||||||....|   ..:.|.:.|.:.....|.::|         ..|....||:
Frog   134 DSAGHGHSHGGHGHSHGAKKSHRPRERAAGESAALDREETNILVENCGNSLAAAAAEGMPGKHDA 198

  Fly   211 ------HGHSHGDMSGSN--------SQI-MRGVFLHILADTLGSVGVIISAVLMH--------- 251
                  .|..:|::..:|        :|: |||||||:|.|.||||.|:::|::.:
Frog   199 LAENIVDGRVNGNVIENNLPEIHEDGTQLNMRGVFLHVLGDALGSVIVVLNALVFYFVFNPCPSD 263

  Fly   252 -----------------------------------MFG--WMI-ADP-ICSIFIALLIALSVLSL 277
                                               |.|  |:: .|| :|.|.:.:|: .:...|
Frog   264 EGCINPCVEDHCDKKVNVSALSSNPDNTSSPPEIQMAGPCWVLYLDPSLCVIMVCILL-YTTYPL 327

  Fly   278 IKESIMILMQRQPADLDRSLPQCYQKVTGLAGVYAVQEPHFWTLCSDVYVGALKLEVSKNVDPKY 342
            :|||.:||:|..|..:|  :....||:..|.||.||.|.|.|.|.....:....::.........
Frog   328 LKESALILLQTVPKQID--ISSLKQKLKNLDGVEAVHELHVWQLAESRIIATAHIKCHDPTAYMD 390

  Fly   343 VVTHTRMIFEAVGVKQIYIQLDY 365
            |....:..|...|:....||.::
Frog   391 VAKRIKDFFHDEGIHATTIQPEF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	118/398 (30%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	98/317 (31%)
slc30a1	NP_001007940.1	CzcD	8..415	CDD:224151	122/409 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950