DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and slc30a6

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_991214.1	Gene:	slc30a6 / 402949	ZFINID:	ZDB-GENE-040426-1838	Length:	486	Species:	Danio rerio

Alignment Length:	348	Identity:	85/348 - (24%)
Similarity:	152/348 - (43%)	Gaps:	42/348 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PLSHKDRSSLGYRIREKLNSWKRLIFSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLISDSF 67
            |.....||.||     ||....||:.|||.|..:.||.:||:......|.:...|||:.|.:.::
Zfish    33 PFRKAHRSVLG-----KLAQEFRLVTSDRRSWKILLFGVLNVVCTGCLLMWCSSTNSMALTAYTY 92

  Fly    68 HMFFDCTGLLAGLAASVITKWKANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPP 132
            ...||...|:..|.:..:|..|.:..:|:|:.|.||||.|.:::.:...:.|||.|.|||.:|.|
Zfish    93 LTIFDLFSLITCLLSLWVTMKKPSQIYSFGFQRFEVLAVFSSTVLVQLGSLFILKESVERFVEQP 157

  Fly   133 EVKHERLFVVSVLGLLVNLVGIYAFNHGGHGHSHGGHGHSHGGGHGHGHSHGHTDAGNHNHQAIT 197
            ||...||.|.:.:.|..||:.:.:..                                 |...:.
Zfish   158 EVHTGRLLVGTFVALFFNLLTLLSVK---------------------------------NKPFVF 189

  Fly   198 LDNGHGHS----HDHDSHGHSHGDMSGSNSQIMRGVFLHILADTLGSVGVIISAVLMHMFGWMIA 258
            :......|    |..|......|.:...:|.::..:...:|.:..|:..:.|:.:|:.:..:...
Zfish   190 VSEAASTSWLQEHVADLSRSLCGLIPALSSFLLPRMNPFVLINLAGAFALGITYMLIEINNYNAM 254

  Fly   259 DPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGVYAVQEPHFWTLCS 323
            |...::.|||:...::..:...|..:|:|..|:.:...|.:..::|:.|.||..|:..||||:..
Zfish   255 DTASAVAIALMTFGTMYPMSVYSGKVLLQTTPSHVIGQLDKLLREVSTLDGVLEVRNEHFWTIGF 319

  Fly   324 DVYVGALKLEVSKNVDPKYVVTH 346
            ....|::.:.:.::.|.:.|:.|
Zfish   320 GSLAGSVHVRIRRDADEQMVLAH 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	68/305 (22%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	51/243 (21%)
slc30a6	NP_991214.1	Cation_efflux	70..282	CDD:279834	51/244 (21%)
slc30a6	NP_991214.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910