DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and slc30a7

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001093556.1	Gene:	slc30a7 / 327439	ZFINID:	ZDB-GENE-030131-5650	Length:	387	Species:	Danio rerio

Alignment Length:	386	Identity:	236/386 - (61%)
Similarity:	288/386 - (74%)	Gaps:	25/386 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIPLSHKD--RSSLGYRIREKLNSWKRLIFSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLI 63
            |:|||.||  .....:.:..||:.|.|.|.:|:.|||||.||.||||||||||.|||.:||||||
Zfish     1 MLPLSIKDDEYKPAKFNLVVKLSGWFRSILADKTSRNLFFFLCLNLSFAFVELLYGIWSNSLGLI 65

  Fly    64 SDSFHMFFDCTGLLAGLAASVITKWKANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERL 128
            |||||||||||.||||||||||::|::||.||||||||||||||||.|||:|.||||.||||||.
Zfish    66 SDSFHMFFDCTALLAGLAASVISRWRSNDSFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERA 130

  Fly   129 IEPPEVKHERLFVVSVLGLLVNLVGIYAFNHGGHGHSHGG--HGHSH-----GGGHGHGH-SHGH 185
            :|||:|.|:||..||:.|||||||||:.|.||||||||||  |||||     ...|||.| .|||
Zfish   131 LEPPDVHHDRLLPVSIAGLLVNLVGIFVFQHGGHGHSHGGDDHGHSHSLFNGSAAHGHSHGGHGH 195

  Fly   186 TDAGN-HNHQAITLDNGHGHSHDHDSHGHSHGDM-----------SGSNSQIMRGVFLHILADTL 238
            :..|: |:|::   .:||.|.|.|..|||||.|.           .||:.||::||||||:||||
Zfish   196 SHGGHGHSHES---KHGHDHGHSHGGHGHSHDDQHCHDDHTLTPGKGSSKQILQGVFLHIVADTL 257

  Fly   239 GSVGVIISAVLMHMFGWMIADPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQK 303
            |||||||||:||..:..||||||||:.|||||.:||:.|::|||.|||||.|..||.:||:|||:
Zfish   258 GSVGVIISAILMQKYDLMIADPICSMLIALLIGVSVVPLLRESIGILMQRTPPSLDHALPECYQR 322

  Fly   304 VTGLAGVYAVQEPHFWTLCSDVYVGALKLEVSKNVDPKYVVTHTRMIFEAVGVKQIYIQLD 364
            |..|.|||.:|||||||||:|||:|.|||.|:.:.|.:::::.|..||..|||:|:|:|::
Zfish   323 VQQLQGVYNLQEPHFWTLCTDVYIGTLKLLVAPDADSRWILSQTHNIFTQVGVRQLYVQIE 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	213/339 (63%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	169/259 (65%)
slc30a7	NP_001093556.1	CDF	48..383	CDD:273544	213/337 (63%)
		Cation_efflux	48..305	CDD:279834	169/259 (65%)
		His-rich loop	161..232		36/73 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..237		30/72 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593555
Domainoid	1	1.000	349	1.000	Domainoid score	I993
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11332
Inparanoid	1	1.050	469	1.000	Inparanoid score	I1491
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D1507860at2759
OrthoFinder	1	1.000	-	-		FOG0002128
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106189
Panther	1	1.100	-	-	LDO	PTHR45755
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1409
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800