DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and Slc30a10

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001028458.1	Gene:	Slc30a10 / 226781	MGIID:	2685058	Length:	470	Species:	Mus musculus

Alignment Length:	375	Identity:	104/375 - (27%)
Similarity:	170/375 - (45%)	Gaps:	41/375 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 FSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLISDSFHMFFDCTGLLAGLAASVIT-KWKAN 91
            :|.:..|.||: |:|..:|...||..|.:.||:.|:||||:|..|...|..||.:..|. :....
Mouse     4 YSGKTCRLLFM-LVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGPRG 67

  Fly    92 DKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPPEVKH-ERLFVVSVLGLLVNLVGIY 155
            ...:||||||||:....|::||..:.|.|..|.|.||..|..:.. |.:.:|..|||.||:||:.
Mouse    68 SSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVVGLL 132

  Fly   156 AFNHGG-------------------HGHSHGGHG------HSHGGGHGHGHSHGHTDAGNHNHQA 195
            .|...|                   .|...|..|      .:...|.|...:...:.||....:.
Mouse   133 IFQDCGACFSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEG 197

  Fly   196 ITL-DNGHGHSHDHDSHGHSHGDMSGSNSQI-MRGVFLHILADTLGSVGVIISAVLMHM------ 252
            .|: .|..|.|.:.::...........:..: :|||.||::.|.||||.|:|:|::.::
Mouse   198 ATVFSNVAGDSLNTENEPEETTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRRE 262

  Fly   253 --FGWM-IADPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGVYAVQ 314
              ..|. ..||..::.:.::|..|...||||:.:||:|..|..:  ::.:...:::.:.|:.:|.
Mouse   263 DPCNWQCYIDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGV--NMEELMSQLSTVPGISSVH 325

  Fly   315 EPHFWTLCSDVYVGALKLEVSKNVDPKYVVTHTRMIFEAVGVKQIYIQLD 364
            |.|.|.|.|...:..|.::..|..:.:......|.||...|:..:.||.:
Mouse   326 EVHIWELISGKIIATLHIKHQKGTEYQDASRKIREIFHHAGIHNVTIQFE 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	98/357 (27%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	80/277 (29%)
Slc30a10	NP_001028458.1	CzcD	10..376	CDD:224151	103/369 (28%)
		Cation_efflux	20..299	CDD:279834	80/278 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..223		11/76 (14%)
		Required for plasma membrane localization. /evidence=ECO:0000250\|UniProtKB:Q6XR72	300..470		17/78 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850