DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and slc-30A5

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_740931.2	Gene:	slc-30A5 / 173299	WormBaseID:	WBGene00013668	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	146/354 - (41%)
Similarity:	202/354 - (57%)	Gaps:	40/354 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SLGYRIREKLNSWKRLIFSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLISDSFHMFFDCTG 75
            ||...::|.||.    |..:.:||.:|.||.:||.|..||..||..|||||||||.|||.|||:.
Worm   383 SLMLFMKETLNE----ILMNNDSRRIFWFLCVNLGFCGVEFLYGFWTNSLGLISDGFHMLFDCSA 443

  Fly    76 LLAGLAASVITKWKANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPPEVKHERLF 140
            |:.||.|||:.:|.....|::|:.|.|:|:||:|:|||..||.|||.|.:|||.:||.:..:||.
Worm   444 LVMGLVASVMARWPPTRHFTFGFGRVEILSGFINALFLCVIALFILIEALERLFDPPNINTDRLL 508

  Fly   141 VVSVLGLLVNLVGIYAFNHGGHGHSHGGHGHSHGGGHGHGHSHGHTDAGNHNHQAITLDNGHGHS 205
            .|::.||:|||.|:|         |.|.||||||||..||||||                |.|
Worm   509 FVAISGLIVNLFGMY---------SLGEHGHSHGGGSSHGHSHG----------------GGG-- 546

  Fly   206 HDHDSHGHSHGDMSGSNSQIMRGVFLHILADTLGSVGVIISAVLMHMFGWMIADPICSIFIALLI 270
                |||||||  .|.|:. |:|||||:||||||||.||||.:|:..|||:..||:||:.::|||
Worm   547 ----SHGHSHG--GGGNAN-MQGVFLHVLADTLGSVFVIISTLLIQWFGWVWVDPLCSLILSLLI 604

  Fly   271 ALSVLSLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGVYAVQEPHFWTLCSDVYVGALKLEVS 335
            ..||..|:..||..|:|..|.  :........::..:..|.:....|.|...||:.|.::.::|.
Worm   605 IGSVYPLLVSSISTLLQDVPE--EEEFEYHINEILEIEHVESYSNAHMWQHKSDINVASVHVQVK 667

  Fly   336 KNVDPKYVVTHTRMIFEAVGVKQIYIQLD 364
            :..:.:.:......|.::.|.....:|::
Worm   668 EEANAQMIRHRVSNILKSTGATHSTVQVE 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	133/319 (42%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	120/239 (50%)
slc-30A5	NP_740931.2	CzcD	397..696	CDD:224151	140/334 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I1375
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2410
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1507860at2759
OrthoFinder	1	1.000	-	-		FOG0002128
OrthoInspector	1	1.000	-	-		oto17252
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1409
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.760