DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT86D and SLC30A7

DIOPT Version :9

Sequence 1:	NP_650049.1	Gene:	ZnT86D / 41342	FlyBaseID:	FBgn0037875	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001138356.1	Gene:	SLC30A7 / 148867	HGNCID:	19306	Length:	376	Species:	Homo sapiens

Alignment Length:	380	Identity:	230/380 - (60%)
Similarity:	281/380 - (73%)	Gaps:	22/380 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIPLSHKD--RSSLGYRIREKLNSWKRLIFSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLI 63
            |:|||.||  .....:.:..|::.|.|.|.||:.|||||.||.||||||||||.|||.:|.||||
Human     1 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLI 65

  Fly    64 SDSFHMFFDCTGLLAGLAASVITKWKANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERL 128
            |||||||||.|.:|||||||||:||:.||.||||||||||||||||.|||:|.||||.||||||.
Human    66 SDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERA 130

  Fly   129 IEPPEVKHERLFVVSVLGLLVNLVGIYAFNHGGHGHSHG-GHGHSHG-------GGHG---HGHS 182
            :.||:|.||||.:||:||.:|||:||:.|.||||||||| ||||||.       ..||   |.||
Human   131 LAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHS 195

  Fly   183 H--GHTDAGNHNHQAITLDNGHGHSHDHDSHGHSHGDMSGSNSQIMRGVFLHILADTLGSVGVII 245
            |  .|..|.:|:|.     :||||.|.||  |.|..:.:|.:.||::|||||||||||||:|||.
Human   196 HEVKHGAAHSHDHA-----HGHGHFHSHD--GPSLKETTGPSRQILQGVFLHILADTLGSIGVIA 253

  Fly   246 SAVLMHMFGWMIADPICSIFIALLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGV 310
            ||::|..||.|||||||||.||:||.:||:.|::||:.|||||.|..|:.|||||||:|..|.||
Human   254 SAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGV 318

  Fly   311 YAVQEPHFWTLCSDVYVGALKLEVSKNVDPKYVVTHTRMIFEAVGVKQIYIQLDY 365
            |::||.||||||||||||.|||.|:.:.|.:::::.|..||...||:|:|:|:|:
Human   319 YSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDF 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT86D	NP_650049.1	CDF	46..366	CDD:273544	207/333 (62%)
ZnT86D	NP_650049.1	Cation_efflux	46..286	CDD:279834	161/252 (64%)
SLC30A7	NP_001138356.1	CzcD	31..374	CDD:224151	220/350 (63%)
		Cation_efflux	48..294	CDD:279834	161/252 (64%)
		His-rich loop	161..218		30/61 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..226		16/38 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157772
Domainoid	1	1.000	328	1.000	Domainoid score	I1169
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11332
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1630
Isobase	1	0.950	-	0	Normalized mean entropy	S2410
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D1507860at2759
OrthoFinder	1	1.000	-	-		FOG0002128
OrthoInspector	1	1.000	-	-		oto88936
orthoMCL	1	0.900	-	-		OOG6_106189
Panther	1	1.100	-	-	LDO	PTHR45755
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1409
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750