Protein Alignment cu and NGL2

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_014012.1
• Gene: NGL2 / 855329
• SGDID: S000004898
• Length: 515
• Species: Saccharomyces cerevisiae
• Alignment Length: 588
• Identity: 123/588 - (20%)
• Similarity: 195/588 - (33%)
• Gaps: 231/588 - (39%)

  Fly   178 MEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFEPPRDLLLYLVRMGSFNSAPKINNVDSQDDG 242
            |..|:::.|.:|                    :..|.:::        ..|.:.|.....:.||
Yeast     1 MTQDKEVKVVAP--------------------DVAPDQEV--------EINKSVKDAKHQTNDD- 36

  Fly   243 LVLPSGLSTPALLQHVQQLRGGGIEQP-----------------------SLLTRGFLKPLLADE 284
                      :||||.::.:.|...:|                       ::|.:|      .|.
Yeast    37 ----------SLLQHKKKGKKGKKSKPIVTPEHIAKVRAEREVMRKAKRDAMLAQG------VDP 85

  Fly   285 DVADGLRCLKLNSVSRVCSAPVEGDDIRLLQWNILSQTLGQHNDGFVR---CPE--EALTWEHRK 344
            |....|..::...:|...:.||.|...:|:.:|.|:|.|       :|   .|:  :||.|..|.
Yeast    86 DCPPELHFIRRPFLSLHEAEPVTGFRFKLMTYNCLAQAL-------IRRKLFPDSGDALKWYRRS 143

  Fly   345 YLIVQEILQNQPDVICLQEVDHFKFLQTVLGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKR 409
            .:::.|......|||||||:||.:|       |::....|.|......|........|.||.::|
Yeast   144 KVLLNEFKYYNSDVICLQEIDHIQF-------QSFWKDEFSKLGYDGQYYRNATKNHGVAIMWRR 201

  Fly   410 ------DKLQLQGYDTRILE--VWRVQSNQVAIAARLRM---------RSSGRE--FCVATTHL- 454
                  ||: |..||....|  ..|..:|.|.:...|:.         :.|.::  ..:.||||
Yeast   202 ELFHQVDKM-LIDYDKESSESISTRTTTNNVGLVLALKFSEKVLSNLGKKSSKKCGILIGTTHLF 265

  Fly   455 --------KARHGALLAK-----------LRNEQGRDLIRFVKQFAGDTPLLLCGDFNAEPVEPI 500
                    :.|...::.|           |:||...||..:...|        |||||::|.:..
Yeast   266 WHPFGTYERTRQCYIVLKKMKEFMHRVNVLQNENDGDLSHWFPFF--------CGDFNSQPFDTP 322

  Fly   501 Y--------------ATILGCDL------LRLGSAYADVKLDRE-----------------EILH 528
            |              .|::||..      :|.|...||   |.|                 |..|
Yeast   323 YLSMTSKPVHYRNRAKTVIGCSTSYKFSKVRDGEEGAD---DEEGGNIEKYGKDQPESPVPEKFH 384

  Fly   529 PNADVGEFVAK-------------------------------SMKREPPYTTWKIREEGEECHTI 562
            .|.:..|.|.|                               :.:.||..:.|.....|    .:
Yeast   385 ANEEQSELVDKMAQLHNSLDMRAISLYSVGYKNVHPENAGLDNDRGEPEISNWANTWRG----LL 445

  Fly   563 DYVFYT--------------------PDRLKIKNCLDFPAGEQIGKNRTPSF-QYPSDHFSLVCD 606
            ||:||.                    .:::|.:..|..|.|.::.|:..|.. :|.|||.|:|||
Yeast   446 DYLFYVKKWDPQSNCQEVETLGDFEKENKVKCRGFLRMPPGNEMTKHGQPHVGEYASDHLSMVCD 510

  Fly   607 FEL 609
            .||
Yeast   511 LEL 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	97/429 (23%)
NGL2	NP_014012.1	CCR4	82..515	CDD:227564	107/468 (23%)