Protein Alignment cu and CCR4

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_009381.1
• Gene: CCR4 / 851212
• SGDID: S000000019
• Length: 837
• Species: Saccharomyces cerevisiae
• Alignment Length: 685
• Identity: 143/685 - (20%)
• Similarity: 227/685 - (33%)
• Gaps: 220/685 - (32%)

  Fly   110 RQSAINEMCQRLCGPECRRPQGLTLDGVRQDFLRQYEIAEAVAKTSAMTSTVQMKQRLAARKLEF 174
            :|.|..:..|::.||....||.........|| :|..||||.......|....|:.   |..|..
Yeast   196 QQQAQQQAQQQVPGPFGPGPQAAPPALQPTDF-QQSHIAEASKSLVDCTKQALMEM---ADTLTD 256

  Fly   175 EKEMEMDEQLGVASPRNDINLGQSST-------VAATGMGEFEFEPPRDLLLYLVRMGSFNSAPK 232
            .|..:..:..|.::|.........||       :.|.|..|     ....||...::..:
Yeast   257 SKTAKKQQPTGDSTPSGTATNSAVSTPLTPKIELFANGKDE-----ANQALLQHKKLSQY----- 311

  Fly   233 INNVDSQDD---GLVLPSGLSTPALLQHVQQLR-------GGGIEQPSLLTRGFLK-----PLLA 282
              ::|..||   .:|:|........|.|...|.       ...|.:...|||.:|.     .|.|
Yeast   312 --SIDEDDDIENRMVMPKDSKYDDQLWHALDLSNLQIFNISANIFKYDFLTRLYLNGNSLTELPA 374

  Fly   283 DEDVADGLRCLKLNSVSRVCSAP------------------------------------VEGDDI 311
            :......||.|.| |.:|:.|.|                                    |||:.:
Yeast   375 EIKNLSNLRVLDL-SHNRLTSLPAELGSCFQLKYFYFFDNMVTTLPWEFGNLCNLQFLGVEGNPL 438

  Fly   312 ---------------------------------RLLQWN-------------------------- 317
                                             |.::.|
Yeast   439 EKQFLKILTEKSVTGLIFYLRDNRPEIPLPHERRFIEINTDGEPQREYDSLQQSTEHLATDLAKR 503

  Fly   318 ---ILS-QTLGQH---NDGFVRCPEEALTWEHRKYLIVQEILQNQPDVICLQEVDHFKFLQ---T 372
               :|| .||.||   ...:...|..||:|::|:..:.::||....|::|||||:...|.:   .
Yeast   504 TFTVLSYNTLCQHYATPKMYRYTPSWALSWDYRRNKLKEQILSYDSDLLCLQEVESKTFEEYWVP 568

  Fly   373 VLGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQLQGYDTRILE-VW----------- 425
            :|....|.|||..|..:..::.:.:...|||.||:|||:.:|...|..... .|
Yeast   569 LLDKHGYTGIFHAKARAKTMHSKDSKKVDGCCIFFKRDQFKLITKDAMDFSGAWMKHKKFQRTED 633

  Fly   426 ----RVQSNQVAIAARLRMRSSGREFCVATTHLKARH-------------GALL----AKLRNEQ 469
                .:..:.||:..:|:...||......||||   |             |.||    ..|:.|.
Yeast   634 YLNRAMNKDNVALFLKLQHIPSGDTIWAVTTHL---HWDPKFNDVKTFQVGVLLDHLETLLKEET 695

  Fly   470 GRDLIRFVKQFAGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNADVG 534
            ..:..:.:|:|    |:|:|||||:.....:|      :|:..|...          :|...:..
Yeast   696 SHNFRQDIKKF----PVLICGDFNSYINSAVY------ELINTGRVQ----------IHQEGNGR 740

  Fly   535 EFVAKSMKR---------------EPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGE 584
            :|...|.|.               |.|:|.:    .......|||::::...|:::..|.....|
Yeast   741 DFGYMSEKNFSHNLALKSSYNCIGELPFTNF----TPSFTDVIDYIWFSTHALRVRGLLGEVDPE 801

  Fly   585 QIGK-NRTPSFQYPSDHFSLVCDFELLPPTENGKE 618
            .:.| ...|:.::||||..|:..||.:......|:
Yeast   802 YVSKFIGFPNDKFPSDHIPLLARFEFMKTNTGSKK 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	87/381 (23%)
CCR4	NP_009381.1	LRR	<339..>439	CDD:443914	19/100 (19%)
		leucine-rich repeat	339..358	CDD:275378	2/18 (11%)
		leucine-rich repeat	359..381	CDD:275378	6/21 (29%)
		leucine-rich repeat	382..404	CDD:275378	8/22 (36%)
		leucine-rich repeat	405..427	CDD:275378	0/21 (0%)
		leucine-rich repeat	428..439	CDD:275378	3/10 (30%)
		CCR4	476..837	CDD:227564	88/388 (23%)