Protein Alignment cu and pde12

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001038753.2
• Gene: pde12 / 692319
• ZFINID: ZDB-GENE-060519-25
• Length: 591
• Species: Danio rerio
• Alignment Length: 628
• Identity: 130/628 - (20%)
• Similarity: 222/628 - (35%)
• Gaps: 215/628 - (34%)

  Fly   116 EMCQRLC-GPECRRPQGLTLDGVRQDFLRQY-----EIAEAVAKTSAMTSTVQMKQRLAARKLEF 174
            |.|...| ..|.:.....:|:|..:..||..     ::.:.:|..|..|:..:.|:...:::...
Zfish    38 ERCVVRCVESESKLTISFSLNGSNKHMLRDKTEPLGKLLDRIANNSVKTTAGKSKKHKPSKEKPE 102

  Fly   175 EKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFEPPRDLLLYLVRMGSFNSAPKINNVDSQ 239
            .:|.:..|                ::::..|      :|               .:|:..|.|:.
Zfish   103 SQEADKPE----------------TSLSVNG------QP---------------VSPETLNSDAW 130

  Fly   240 DDGLVLPSG-------LSTPALLQHVQQLRGGGIEQPSLLTRGF-LKPLLADE--DVAD------ 288
            :||.||..|       .:.|...|         .|.||.|..|| :.|.:..|  |:.|
Zfish   131 EDGAVLQVGDLQYKVERNPPTFTQ---------CELPSSLMAGFPVCPKIEIEFGDLKDCEFSWF 186

  Fly   289 --------------------------------GLRCL---------------KLNSVSRVCSAP- 305
                                            |||.:               ||.|.|.|.:.|
Zfish   187 KESSASAYITGDAECWREAGSERVFTPSNLDIGLRLMLKCTPGDGSKIGEPKKLVSSSAVEAGPG 251

  Fly   306 --------------VEGDDIRLLQWNILSQTLGQHNDG----FVRCPEEALTWEHRKYLIVQEIL 352
                          .:...:|::.:|||:....|.:..    :..|...||..::|:.||.:|:.
Zfish   252 ICTFDNRHIYTQKLTDEGSLRVVSYNILADVYAQTDLSKTVLYPYCAPYALQMDYRQNLIKKELS 316

  Fly   353 QNQPDVICLQEVDHFKFLQTV---LGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQL 414
            ....|:|||||||...|:..:   |.:....|:|..|        |:.:  :|.|.:::|.||:|
Zfish   317 GYNADIICLQEVDKCVFVDLLCPALDAFGLDGVFRIK--------EKQH--EGLATYFRRSKLKL 371

  Fly   415 -QGYDTRILE----------VWRVQSNQVAIAARLRMRSS-------------GREFCVATTHLK 455
             :.||..:.|          :|...|...::..::..||:             .|..||..|||.
Zfish   372 VEQYDVMLSEALTTDPIHRQLWEKVSCSPSLKEKIEKRSTTLQVTVLQSLCDPSRILCVGNTHLY 436

  Fly   456 ARHGALLAKLRNEQGRDLIRFVKQFAGD----TPLLLCGDFNAEPVEPIYATI-LGC-------- 507
            .|...  ..:|..|....:..:||...:    ..|:..||||:.|...::..: .||
Zfish   437 WRPEG--GNVRLVQIAVALEHMKQVVTEKHPGARLIFSGDFNSTPSSGLFQLLSQGCIPEDHEDW 499

  Fly   508 ------DLLRLGSAYADVKLDREEILHPNADVGEFVAKSMKREPPYTTWKIREEGEECHTIDYVF 566
                  :.:|||            :.:|      |...|....|.:|.:....:|  |  :||:|
Zfish   500 GSGGPEEQIRLG------------LTNP------FQLSSACGVPDFTNFVGGFQG--C--LDYIF 542

  Fly   567 YTPDRLKIKNCLDFPAGEQIGK-NRTPSFQYPSDHFSLVCDFE 608
            ..|..|:::..:..|:.|::.. ...||..:||||.:||||.:
Zfish   543 VEPRTLQVEQVIPLPSLEEVSNCVALPSISHPSDHIALVCDLK 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	85/348 (24%)
pde12	NP_001038753.2	EEP	273..586	CDD:469791	84/347 (24%)