DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cu and Lrrc27

DIOPT Version :9

Sequence 1:	NP_001097746.1	Gene:	cu / 41339	FlyBaseID:	FBgn0261808	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001137228.1	Gene:	Lrrc27 / 499281	RGDID:	1559981	Length:	513	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	87/451 - (19%)
Similarity:	140/451 - (31%)	Gaps:	155/451 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 INLGQSSTVAATGMGEFEFEPPRDLLLY--LVRMGSFNSAPKINNVDSQDDGLV-LPSGLSTPAL 254
            :.|||.:|:.|..:.....|.|..|::.  ||.:.:|.....:.|....|:.|. :|:..|...|
  Rat   132 VELGQVTTLTALNLRHCPLEFPPYLIVQKGLVSILTFLRICSVENAFPGDESLPGVPTAKSDLLL 196

  Fly   255 -LQHVQQLRGGG---IEQPSLLTR---GFLKPLLADEDVADGLRCLKLNSVSRVCSAPVEGDDIR 312
             |.|.......|   ::|.:.:.:   .|..|:    |..|.....|.:|.|.:..:.   ::||
  Rat   197 PLPHKDLSSENGLNVLDQEAAVVKEKGDFFPPM----DRLDLSELRKSSSSSEIWPSK---EEIR 254

  Fly   313 LLQWNILSQTLGQHNDGFVRCPEEALTWEHRKYLIVQEILQNQPDVICLQEVDHFKFLQTVL--- 374
            ..                         |:.|     |||::|:.     .||...|.|...|
  Rat   255 RF-------------------------WKLR-----QEIVENEQ-----VEVQENKLLAVELPPN 284

  Fly   375 ---------------------GSQNYAGIFFPKPDSPCLY---IEQNNGPDGCAIFY-----KRD 410
                                 .|.::.||.   |:....|   :......|...:.:     |..
  Rat   285 LKAAINAKERKCRKPWPTLRKRSTSFRGIL---PNLSSTYQNTVHTKRMDDTHKMAFQELQEKER 346

  Fly   411 KLQLQGYDTRILEVWRVQSNQVAIAARLRMRSSGREFCVATTHLKARHGALLAKLRNEQGRDLIR 475
            .|:.|..|.|.|:.||.|:.      .:|.|   |||    :..:..|       ||.....:
  Rat   347 MLEQQRRDKRALQDWREQTQ------LMRHR---REF----SKFQPLH-------RNTMASKI-- 389

  Fly   476 FVKQFAGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNADVG------ 534
               .||.|..     |:...|..|                :..||..||.|.....::.
  Rat   390 ---PFATDLT-----DYEKMPASP----------------FGKVKPRREGIAQKRIEISTSPLAE 430

  Fly   535 ----------EFVAKSMKREPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLD----FP 581
                      :..|:|.....|  |..|:...::..|...:.....|||::..|:    ||
  Rat   431 LEDKIRRHTQQIRARSFLGTNP--TQDIKTANQDLETTKKLQEELRRLKLEMTLNKDHSFP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:382041	58/322 (18%)
Lrrc27	NP_001137228.1	PLN00113	30..>173	CDD:215061	11/40 (28%)
		leucine-rich repeat	50..69	CDD:275378
		LRR_8	68..127	CDD:404697
		leucine-rich repeat	70..93	CDD:275378
		leucine-rich repeat	94..116	CDD:275378
		leucine-rich repeat	117..139	CDD:275378	3/6 (50%)
		leucine-rich repeat	140..151	CDD:275378	1/10 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900