DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cu and Noct

DIOPT Version :9

Sequence 1:	NP_001097746.1	Gene:	cu / 41339	FlyBaseID:	FBgn0261808	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_612535.1	Gene:	Noct / 310395	RGDID:	1587344	Length:	428	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	174/430 - (40%)
Similarity:	229/430 - (53%)	Gaps:	56/430 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 GQSSTVAATGMGEFEFEPPRDLLLYLVRMGSFNSAPKINNVDSQDDGL-----VLPSGLSTPALL 255
            |...|:|...:|.....|.    |.....|:..|.|:  .|....:|.     .|...:::.|..
  Rat    27 GPRRTLAPPVLGSRPASPQ----LQAAASGAARSRPR--TVSPMGNGTSRLYSALAKTINSSAAA 85

  Fly   256 QHVQQLRGGG------IEQPSLL--TRGFL--KPLLADEDVADGLRCLKLNSVSRVCSAPVEGDD 310
            ||.:.|....      |:...||  .|..|  :|.....|..|    |:.:     ||:  ....
  Rat    86 QHPEYLVSADPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVD----LRTD-----CSS--SHPP 139

  Fly   311 IRLLQWNILSQTLGQHNDGFVRCPEEALTWEHRKYLIVQEILQNQPDVICLQEVDH-FKFLQTVL 374
            ||::|||||:|.||:..|.||:||.|||.||.||.||::|||..|||::||||||| |...|.:|
  Rat   140 IRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLL 204

  Fly   375 GSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQLQGYDTRILEVWRVQSNQVAIAARLR 439
            ....|.|.|||||.||||.:|.||||||||:|:.:.:.:|.......|....:::||||||..|.
  Rat   205 SRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQSRFKLINSTNIRLTAMTLKTNQVAIAQTLE 269

  Fly   440 MRSSGREFCVATTHLKARHGALLAKLRNEQGRDLIRFVKQF--AGDTPLLLCGDFNAEPVEPIYA 502
            .:.|||:||:|.||||||.|  ..:.|:.||.||::.::..  ....||::||||||||.|.:|.
  Rat   270 CKESGRQFCIAVTHLKARTG--WERFRSAQGCDLLQNLQNITEGAKIPLIVCGDFNAEPTEEVYK 332

  Fly   503 TILGCDLLRLGSAYADVKLDREEILHPNADVGEFVAKSMKREPPYTTWKIREEGEECHTIDYVFY 567
            ...... |.|.|||        ::|.|:.          :.||||||||||..||..||:||::|
  Rat   333 HFASSS-LNLNSAY--------KLLSPDG----------QSEPPYTTWKIRTSGECRHTLDYIWY 378

  Fly   568 TPDRLKIKNCLDFPAGEQIGKNRTPSFQYPSDHFSLVCDF 607
            :...|.:.:.||....||||.||.|||.|||||.||||||
  Rat   379 SRHALSVTSALDLLTEEQIGPNRLPSFHYPSDHLSLVCDF 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:382041	146/299 (49%)
Noct	NP_612535.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..66		10/44 (23%)
		Deadenylase_nocturnin	141..420	CDD:197330	146/299 (49%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	216..218		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	283..286		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	321..323		1/1 (100%)
		Interaction with PPARG. /evidence=ECO:0000250\|UniProtKB:O35710	340..350		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353886
Domainoid	1	1.000	235	1.000	Domainoid score	I2298
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7661
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59827
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007080
OrthoInspector	1	1.000	-	-		oto98890
orthoMCL	1	0.900	-	-		OOG6_105986
Panther	1	1.100	-	-	LDO	PTHR12121
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3966
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.710