Protein Alignment cu and Pde12

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001398637.1
• Gene: Pde12 / 306231
• RGDID: 1310975
• Length: 608
• Species: Rattus norvegicus
• Alignment Length: 662
• Identity: 162/662 - (24%)
• Similarity: 234/662 - (35%)
• Gaps: 238/662 - (35%)

  Fly   127 RRPQGLTLDGVRQDFLRQYEIAEAV------AKTSAMTSTVQMKQRLAARKLEF------EKEME 179
            |.|....|.||| ..:.|...|||.      |...|:...|..:.:|:   |.|      .|.|:
  Rat     3 RLPGRAALRGVR-SVVEQRSPAEATTHEAVRAMERAVVRCVPSEPKLS---LSFALADGSHKNMQ 63

  Fly   180 MD--EQLGVA--------------------SPRNDINLGQSSTVAATGMGEFEFEP-----PRDL 217
            .|  |.||.|                    |.:|..:....:..||||.     ||     |...
  Rat    64 RDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSSGGAACAATGS-----EPAATCEPVVK 123

  Fly   218 LLYLVRMGSFNSAPKINNVDSQDDGLVLPSG-------LSTPALLQHVQQLRGGGIEQPSLLTRG 275
            |.|....    .|..:.|||:..||.||..|       .:.||..:         ::.|..:..|
  Rat   124 LYYREEA----VAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTE---------LQLPRYIMAG 175

  Fly   276 F-----------------------LKPLLA------------------------DEDV-----AD 288
            |                       :||..|                        ||.|     ||
  Rat   176 FPVCPKLGLEFGDPASSVFRWYKEVKPGAAEPGDSGLASSSHSLQSSAWIETGVDERVYTPCNAD 240

  Fly   289 -GLRCLKLN-------------SVSRVCSAPVEG------------------DD--IRLLQWNIL 319
             ||| |||:             .:..||  |||.                  :|  ||.:.:|||
  Rat   241 IGLR-LKLHCTPGNGQRFGPSRELESVC--PVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYNIL 302

  Fly   320 SQTLGQHNDGFVR------CPEEALTWEHRKYLIVQEILQNQPDVICLQEVDHFKF---LQTVLG 375
            :.|..|..  |.|      |...||..::|:.||.:|:.....|:|||||||...|   |...|.
  Rat   303 ADTYAQTE--FSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPALE 365

  Fly   376 SQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQ-LQGYDTRILEVWR------------- 426
            :....|:|         .|:|:   :|.|.||::.|.: |..:|....|..:
  Rat   366 AFGLEGVF---------RIKQH---EGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEKLA 418

  Fly   427 ----------VQSNQVAIAARLRMRSSGREFCVATTHLKAR-HGALLAKLRNEQGRDLIRFVK-- 478
                      .:|:.:.|:.......|.::.|||.|||... .|..:..::.......||.|.
  Rat   419 LNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMAAALVHIRHVSCD 483

  Fly   479 QFAGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNADVGE-------- 535
            .:.| .|::.|||||:.|...:|..::.      ||    |..|.|:.    |..||
  Rat   484 LYPG-IPVIFCGDFNSTPSTGMYHFVIN------GS----VPEDHEDW----ASNGEEERCGMSL 533

  Fly   536 ---FVAKSMKREPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGEQIGKNRT-PSFQY 596
               |..||...||.||.:.....|  |  :||:|...:.|:::..:..|:.|::..::. ||..:
  Rat   534 THCFKLKSACGEPAYTNYVGGFHG--C--LDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSH 594

  Fly   597 PSDHFSLVCDFE 608
            ||||.:||||.:
  Rat   595 PSDHIALVCDLK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	93/345 (27%)
Pde12	NP_001398637.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..111		4/19 (21%)
		EEP	298..607	CDD:469791	92/342 (27%)