Protein Alignment cu and NOCT

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_036250.2
• Gene: NOCT / 25819
• HGNCID: 14254
• Length: 431
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 194/540 - (35%)
• Similarity: 253/540 - (46%)
• Gaps: 127/540 - (23%)

  Fly    96 CSNCL-KTAPGHLIDRQSAINEMCQRLCGPECRRPQGLTLDGVRQDFLRQYEIAEAVAKTSAMTS 159
            ||..| :.|||            .:||..|..|||                     ::..:|:
Human     9 CSALLQRDAPG------------LRRLPAPGLRRP---------------------LSPPAAV-- 38

  Fly   160 TVQMKQRLAARKLEFEKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFEPPRDLLLYLVRM 224
                 .|.|:.:|           |..||..:......|.||.:.|.|...        ||....
Human    39 -----PRPASPRL-----------LAAASAASGAARSCSRTVCSMGTGTSR--------LYSALA 79

  Fly   225 GSFNSAPKINNVDSQDDGLVLPSGLSTPALLQHVQQLRGGGIEQPSLL--TRGFL--KPLLADED 285
            .:.||:.    .....:.||.|..       :|::.     |:...||  .|..|  :|.....|
Human    80 KTLNSSA----ASQHPEYLVSPDP-------EHLEP-----IDPKELLEECRAVLHTRPPRFQRD 128

  Fly   286 VADGLRCLKLNSVSRVCSAPVEGDDIRLLQWNILSQTLGQHNDGFVRCPEEALTWEHRKYLIVQE 350
            ..| ||          ...|.....||::|||||:|.||:..|.||:||.|||.||.||.||::|
Human   129 FVD-LR----------TDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEE 182

  Fly   351 ILQNQPDVICLQEVDH-FKFLQTVLGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQL 414
            ||..|||::||||||| |...|.:|....|.|.|||||.||||.:|.||||||||:|:.:::.:|
Human   183 ILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKL 247

  Fly   415 QGYDTRILEVWRVQSNQVAIAARLRMRSSGREFCVATTHLKARHGALLAKLRNEQGRDLIRFVKQ 479
            .......|....:::||||||..|..:.|||:||:|.||||||.|  ..:.|:.||.||::.::.
Human   248 VNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTG--WERFRSAQGCDLLQNLQN 310

  Fly   480 F--AGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNADVGEFVAKSMK 542
            .  ....||::||||||||.|.:|....... |.|.|||..:..|.:.
Human   311 ITQGAKIPLIVCGDFNAEPTEEVYKHFASSS-LNLNSAYKLLSADGQS----------------- 357

  Fly   543 REPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGEQIGKNRTPSFQYPSDHFSLVCDF 607
             ||||||||||..||..||:||::|:...|.:::.||....||||.||.|||.|||||.||||||
Human   358 -EPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDF 421

  Fly   608 ELLPPTENGKESGSGSGSDG 627
            ..   ||.         |||
Human   422 SF---TEE---------SDG 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	145/299 (48%)
NOCT	NP_036250.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..41		7/48 (15%)
		Deadenylase_nocturnin	144..423	CDD:197330	145/299 (48%)
		Interaction with PPARG. /evidence=ECO:0000250|UniProtKB:O35710	343..353		4/9 (44%)