Protein Alignment cu and ANGEL1

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001357675.1
• Gene: ANGEL1 / 23357
• HGNCID: 19961
• Length: 744
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 127/553 - (22%)
• Similarity: 193/553 - (34%)
• Gaps: 195/553 - (35%)

  Fly    24 MPVTALLLNLESNPLDYSRNDIGAELLEDDDKPPQLFSVTDEPPSPNEEDYKPPNHHEDDGKLAG 88
            :|.|.|...| |:.....|.::   ||.:...|.........|..|.:|        |.:|.|
Human    11 LPATRLFRAL-SDAFFTCRKNV---LLANSSSPQVEGDFAMAPRGPEQE--------ECEGLL-- 61

  Fly    89 ERHREIPCSNCLKTA-PGHLIDRQSAINEMCQRLCGPECRRPQGLTLDGVRQDFLRQYEIAEAVA 152
            ::.||...|..|.|| .|.|||:..|.:.:...:..|                       .|..|
Human    62 QQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNP-----------------------GEENA 103

  Fly   153 KTSAMTSTVQMKQRLAARKLEFEKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFEPPRDL 217
            .:....|:.|:....||..|: |...||              ||:...:...|:
Human   104 ASEDRWSSRQLSDLRAAENLD-EPFPEM--------------LGEEPLLEVEGV----------- 142

  Fly   218 LLYLVRMGSFNSAPKINNVDSQDDGLVLPSG-LST------PALL-------------------Q 256
                  .||..:|..:.:.....|...||.| |:|      ||:|                   :
Human   143 ------EGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFE 201

  Fly   257 HVQQLRGGGIEQP--SLLTRGFLKPLLADEDV-----ADGLRCLKLNSVSRVCSAPVEGD----D 310
            .:.||:...:|.|  .:|.|.:       ||.     |.||:.               ||    .
Human   202 GLGQLQPPAVEIPYHEILWREW-------EDFSTQPDAQGLKA---------------GDGPQFQ 244

  Fly   311 IRLLQWNILSQTL-GQHNDGFVRCPEEALTWEHRKYLIVQEILQNQPDVICLQEV--DHF-KFLQ 371
            ..|:.:|||:|.| .|.::.::.|..:.|.|.:|...::||.....||::|||||  ||: :.|:
Human   245 FTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLE 309

  Fly   372 TVLGSQNYAGIFFPKPDSPCLYIEQNNG--PDGCAIFYK---------------RDKLQLQGYDT 419
            ..|....:.          |.| ::..|  .||||:.||               |..|:|...|.
Human   310 PSLRMMGFT----------CFY-KRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDN 363

  Fly   420 RILEVWRVQS------NQVAIAARLRMRSSGREFCVATTHL----------KARHGALLAKLRNE 468
            ..| |..:|.      .||::|          ..|||.||:          .|:...|||::
Human   364 VGL-VLLLQPLVPEGLGQVSVA----------PLCVANTHILYNPRRGDVKLAQMAILLAEV--- 414

  Fly   469 QGRDLIRFVKQFAGDTPLLLCGDFNAEPVEPIY 501
               |.:..:.. ....|::||||.|:.|..|:|
Human   415 ---DKVARLSD-GSHCPIILCGDLNSVPDSPLY 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	62/227 (27%)
ANGEL1	NP_001357675.1	EEP	248..>449	CDD:469791	61/225 (27%)