Protein Alignment cu and Pde12

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_848783.3
• Gene: Pde12 / 211948
• MGIID: 2443226
• Length: 608
• Species: Mus musculus
• Alignment Length: 535
• Identity: 133/535 - (24%)
• Similarity: 203/535 - (37%)
• Gaps: 148/535 - (27%)

  Fly   171 KLEFEKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFE--PPRDLLLYLVR--MGSFNSAP 231
            ||.:.:|...::.|       :::..|...|...|..:::.|  ||....|.|.|  |..|...|
Mouse   123 KLYYREEAVAEDVL-------NVDAWQDGAVLQIGDVKYKVERNPPTFTELQLPRYIMAGFPVCP 180

  Fly   232 KINNVDSQD-------------DGLVLPSGLSTPALLQHVQQLRGGGIEQPSL-----LTRGFLK 278
            |: .|:..|             .|...| |.|.||...|        ..|||.     :......
Mouse   181 KL-GVEFGDPASSVFRWYKEVKPGAAEP-GDSGPASSSH--------SSQPSAWIETGVDERVYT 235

  Fly   279 PLLADEDVADGLRCL-----------KLNSVSRVCSAP---------------VEGDDIRLLQWN 317
            |..||..:...|.|.           :|.|:..|.:.|               .|...||.:.:|
Mouse   236 PCNADIGLRLRLHCTPGNGQRFGPSRELESLCPVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYN 300

  Fly   318 ILSQTLGQHNDGFVR------CPEEALTWEHRKYLIVQEILQNQPDVICLQEVDHFKF---LQTV 373
            ||:.|..|..  |.|      |...||..::|:.||.:|:.....|:|||||||...|   |...
Mouse   301 ILADTYAQTE--FSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPA 363

  Fly   374 LGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQ-LQGYDTRILEVWR----------- 426
            |.:....|:|         .|:|:   :|.|.||::.|.: |..:|....|..:
Mouse   364 LEAFGLEGVF---------RIKQH---EGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEK 416

  Fly   427 ------------VQSNQVAIAARLRMRSSGREFCVATTHLKAR-HGALLAKLRNEQGRDLIRFVK 478
                        .:|:.:.|:.......|.::.|||.|||... .|..:..::.|.....||.|.
Mouse   417 LALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMEVALVHIRHVS 481

  Fly   479 Q--FAGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPN-ADVGE----- 535
            :  :.| .|::.|||||:.|...:|..::.      ||...|         |.: |..||
Mouse   482 RDLYPG-IPVIFCGDFNSTPSTGMYHFVIS------GSIAED---------HEDWASNGEEERCS 530

  Fly   536 ------FVAKSMKREPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGEQIGKNRT-PS 593
                  |..||...||.||.:.....|  |  :||:|...:.|:::..:..|:.|::..::. ||
Mouse   531 MPLSHCFKLKSACGEPAYTNYVGGFHG--C--LDYIFIDLNTLEVEQVIPLPSHEEVTTHQALPS 591

  Fly   594 FQYPSDHFSLVCDFE 608
            ..:||||.:||||.:
Mouse   592 VSHPSDHIALVCDLK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	93/346 (27%)
Pde12	NP_848783.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..111
		EEP	298..607	CDD:469791	92/343 (27%)