Protein Alignment cu and PDE12

DIOPT Version :10

• Sequence 1: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_808881.3
• Gene: PDE12 / 201626
• HGNCID: 25386
• Length: 609
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 130/538 - (24%)
• Similarity: 206/538 - (38%)
• Gaps: 154/538 - (28%)

  Fly   171 KLEFEKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFE--PPRDLLLYLVR--MGSFNSAP 231
            ||.:.:|...::.|       :::..|...|...|..:::.|  ||....|.|.|  |..|...|
Human   124 KLYYREEAVAEDVL-------NVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVCP 181

  Fly   232 KINNVDSQDDGLVLPSGLSTPALLQHVQQLRGGGIEQ----PSLLTRGFLKPLLADEDVAD---- 288
            |::          |..|....:|.:..::.:.|..|.    ||.|:.........:.||.:
Human   182 KLS----------LEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYT 236

  Fly   289 ------GLR----CL-----------KLNSVSRVCSAP---------------VEGDDIRLLQWN 317
                  |||    |.           :|.||..|.:.|               .|...||.:.:|
Human   237 PSNADIGLRLKLHCTPGDGQRFGHSRELESVCVVEAGPGTCTFDHRHLYTKKVTEDALIRTVSYN 301

  Fly   318 ILSQTLGQHNDGFVR------CPEEALTWEHRKYLIVQEILQNQPDVICLQEVDHFKF---LQTV 373
            ||:.|..|..  |.|      |...||..::|:.||.:|:.....|||||||||...|   |...
Human   302 ILADTYAQTE--FSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDSLVPA 364

  Fly   374 LGSQNYAGIFFPKPDSPCLYIEQNNGPDGCAIFYKRDKLQLQG------YDT------------- 419
            |.:....|:|         .|:|:   :|.|.||::.|..|..      |:.
Human   365 LEAFGLEGVF---------RIKQH---EGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEK 417

  Fly   420 ---------RILEVWRVQSNQVAIAARLRMRSSGREFCVATTHLKAR-HGALLAKLRNEQGRDLI 474
                     ::|:    :|:.:.::.....:.|.:..|||.|||... .|..:..::.......|
Human   418 LVLYPSAQEKVLQ----RSSVLQVSVLQSTKDSSKRICVANTHLYWHPKGGYIRLIQMAVALAHI 478

  Fly   475 RFVK--QFAGDTPLLLCGDFNAEPVEPIYATILGCDLLRLGSAYADVKLDREEILHPNADVGE-- 535
            |.|.  .:.| .|::.|||||:.|...:|..::.      ||    :..|.|:.    |..||
Human   479 RHVSCDLYPG-IPVIFCGDFNSTPSTGMYHFVIN------GS----IPEDHEDW----ASNGEEE 528

  Fly   536 ---------FVAKSMKREPPYTTWKIREEGEECHTIDYVFYTPDRLKIKNCLDFPAGEQIGKNRT 591
                     |..||...||.||.:.....|  |  :||:|...:.|:::..:..|:.|::..::.
Human   529 RCNMSLTHFFKLKSACGEPAYTNYVGGFHG--C--LDYIFIDLNALEVEQVIPLPSHEEVTTHQA 589

  Fly   592 -PSFQYPSDHFSLVCDFE 608
             ||..:||||.:||||.:
Human   590 LPSVSHPSDHIALVCDLK 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cu	NP_001097746.1	EEP	312..609	CDD:469791	92/349 (26%)
PDE12	NP_808881.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..230		4/23 (17%)
		EEP	299..608	CDD:469791	91/346 (26%)