DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	528	Identity:	155/528 - (29%)
Similarity:	246/528 - (46%)	Gaps:	99/528 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LAVFPFPGRSQYIFAEQFMKELAHRGHNVTV----IN----------------TFGSDKNEPNFR 79
            |.|.|..| |.::..::.::.|:.|||::.|    :|                |:..::.:..||
Mouse    29 LLVVPQDG-SHWLSMKEIVEHLSERGHDIMVLVPEVNLLLGESKYYRRKIFSVTYSLEELQTRFR 92

  Fly    80 VIGAKKIHEIMAAFGNADYTQTAS--------QWQMLTMTTQFLNLLTTSILDDAAVKDLLNSGE 136
                        .|||..:...||        :..|:.:...|.|  ..|:|.|:|....|.. .
Mouse    93 ------------TFGNNHFLPGASLMGPLREYRNNMIVVDMFFSN--CQSLLKDSATLSFLRE-N 142

  Fly   137 KFDLVIMEAVQTEALF-------GLIQHFGAETIGISSY----GTDTHIDELMG-NISPLSYNPL 189
            |||          |||       |:|.   ||.:.:.|.    |....::.::| :.||:||.|.
Mouse   143 KFD----------ALFTDPAMPCGVIL---AEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPR 194

  Fly   190 LLSSRTEQMDFKDR----VMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSL--DEVLDSF- 247
            ..:..::.|.|..|    ::|:.|..:.:.            ||:||...|...|  |..|.|.
Mouse   195 FYTKFSDHMTFPQRLANFIVNILENYLYYC------------LYSKYEIIASDLLKRDVSLPSLH 247

  Fly   248 --ALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNI 309
              :|.||...|...||||.:||||.:||::.::|.|   |.:|...:|..| |.|::.||:||.:
Mouse   248 QNSLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGK---LTQEFEAYVNASGEHGIVVFSLGSMV 309

  Fly   310 KSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGG 374
              .::|......:.:....:||.|||::...:......|..:.||.||.|:|.||..:.||||.|
Mouse   310 --SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSG 372

  Fly   375 LLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAA 439
            .....|.|..|.|::.:|:|.||..|.:|.:..|.|::.::..:.|.:|...::.:::|.||...
Mouse   373 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 437

  Fly   440 AQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLL 504
            ....|.|.:|:....|:.|::|.|||:|||||.|||.|:.||.:.|:|.||..|.|:||.   |.
Mouse   438 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIV---LT 499

  Fly   505 IVVILIKC 512
            :|.|:.||
Mouse   500 VVFIVFKC 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	136/488 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	150/508 (30%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	152/522 (29%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	155/528 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840677
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690