DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	156/557 - (28%)
Similarity:	274/557 - (49%)	Gaps:	73/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEP 76
            :||:.:.:.|.:.     ...::| |:|.. .|.::..:..::||..:||.|||:....|...:|
  Rat     9 LLLLQISFCFKSG-----NCGKVL-VWPME-YSHWMNIKIILEELVQKGHEVTVLRPSASVFLDP 66

  Fly    77 NFRVIGAKKIHEIMAAFGNAD----YTQTASQWQML----TMTTQFLNLLTTSILDD------AA 127
              :.....|......:|.:.|    :|:..:.|...    |..:.||.|..|  :|:      ..
  Rat    67 --KETSDLKFVTFPTSFSSHDLENFFTRFVNVWTYELPRDTCLSYFLYLQDT--IDEYSDYCLTV 127

  Fly   128 VKDLLNSGE--------KFDLVIMEAVQT--EALFGLIQHFGAETIGIS-SYGTDTHIDELMGNI 181
            .|:.:::.:        |||:|..:|:..  |.:..|:|.....::..| .|..:.:|.   |.:
  Rat   128 CKEAVSNKQFMTKLQESKFDVVFSDAIGPCGELIAELLQIPFLYSLRFSPGYTIEKYIG---GVL 189

  Fly   182 SPLSYNPLLLSSRTEQMDFKDRVMNV-----FEASVMWLHKRIVHLPSQRD-----LYAKYF--P 234
            .|.||.|::.|....||.|.:||.|:     |:   .|..       :.|:     .|:|..  |
  Rat   190 FPPSYVPMIFSGLAGQMTFIERVHNMICMLYFD---FWFQ-------TFREKKWDPFYSKTLGRP 244

  Fly   235 TARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EK 298
            |   :|.|::....:.|:..::.|.:|.|..||:..:||||.   :..:||.|::.:||:.| |.
  Rat   245 T---TLAEIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHC---KPAKPLPKDIEDFVQSSGEH 303

  Fly   299 GVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAH 363
            ||:.||:||.:  :::......::....|.:||:|||:|:..:.|....|..:.||.||.|:|.|
  Rat   304 GVVVFSLGSMV--RNMTEEKANIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGH 366

  Fly   364 PNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQ 428
            |..|.|:||||.....|:|:.|.|::|:|:|.:||.|:......|..:..:..:::.:::...::
  Rat   367 PKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALE 431

  Fly   429 ELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWG 493
            |:::||.|...|...|.:..||....|:||::|.|:|:|||||||||....:|.:.|:|.||..|
  Rat   432 EVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIG 496

  Fly   494 LLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            .|:....|:   ||:.:||...|:...:.|.:|.:.|
  Rat   497 FLLTCVAVT---VVLALKCFLFVYRFFVKKEKKTKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	135/492 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	147/508 (29%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	151/532 (28%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	78/223 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344078
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690