Protein Alignment Ugt35A1 and UGT2A3

DIOPT Version :9

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 149/530 - (28%)
• Similarity: 254/530 - (47%)
• Gaps: 81/530 - (15%)

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFGSDKNEP---NFRVIGAKKIHEIMAAFGNADYTQT---- 101
            |.::..:..::||..|||.|||:.     .::|   ::|...|.|...:.......:..:.
Human    34 SHWLNVKVILEELIVRGHEVTVLT-----HSKPSLIDYRKPSALKFEVVHMPQDRTEENEIFVDL 93

  Fly   102 -------ASQWQMLTMTTQF-------LNLLTTS-ILDDAAVKDLLNSGEKFDLVIMEAV----- 146
                   .|.||.:.....|       |.::..| |.:...:|.|..:  .:|:::::.|
Human    94 ALNVLPGLSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKLQET--NYDVMLIDPVIPCGD 156

  Fly   147 -QTEAL---FGLIQHFGAETIGISSYGTDTHIDELMGNI-SPLSYNPLLLSSRTEQMDFKDRVMN 206
             ..|.|   |.|       |:.||..|   :::...|.: :||||.|:.::..|::|.|.:||.|
Human   157 LMAELLAVPFVL-------TLRISVGG---NMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKN 211

  Fly   207 VFEASVM---WLHKRIVHLPSQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYPRPYLP 266
            .. .||:   |:.....|.  ..:.|:|..  ||   :|.|.:....:.|:..::...:|:||.|
Human   212 SM-LSVLFHFWIQDYDYHF--WEEFYSKALGRPT---TLCETVGKAEIWLIRTYWDFEFPQPYQP 270

  Fly   267 NMIEVGGLHLQQKR---KVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFA 327
            |...|||||.:..:   |:....:|:..||:.| |.|::.||:||..  :::......::....|
Human   271 NFEFVGGLHCKPAKALPKINFYLQEMENFVQSSGEDGIVVFSLGSLF--QNVTEEKANIIASALA 333

  Fly   328 SVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPI 388
            .:||:|||:::.    :||.    |..:..|.||.|:|.||..|.||||||:....|:||.|.|:
Human   334 QIPQKVLWRYKG----KKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPM 394

  Fly   389 LGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKET 453
            :|:|||.||..|:...|..|..:..:..::.:.:|...::.::::.||...|...|::..||...
Human   395 VGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVK 459

  Fly   454 ALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFV 518
            .|:||::|.|:|:|||||||||.|:.||.:.|.:.:|..|.|:|....:   :.:..||    |:
Human   460 PLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATA---IFLFTKC----FL 517

  Fly   519 SLISKIRKNR 528
            ....|..|.|
Human   518 FSCQKFNKTR 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	132/474 (28%)
		UDPGT	55..526	CDD:278624	146/515 (28%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	149/530 (28%)
		egt	<267..498	CDD:223071	84/236 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150230
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690