DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	539	Identity:	157/539 - (29%)
Similarity:	263/539 - (48%)	Gaps:	74/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI---NTFGSDKNEPNF 78
            :|.:|.:..|.|    :|| |.|..| |.::..:..:|.|..:||.|.||   |::...:|...:
Zfish    38 VITIFGSLCDGG----KIL-VAPLEG-SHWVNMDILIKALHGQGHTVDVIRNANSWFIKENSTYY 96

  Fly    79 RVI---GAKKIHEIMAA---FGNADYTQTASQWQMLTMTTQFLNL-------------LTTSILD 124
            ..|   ..|...|..||   :....|.:....|  |::...:||:             |.|:|||
Zfish    97 DTITIPNTKGWDEEFAADFVYKMIKYEKEKGSW--LSIVRLYLNVFDAVKKTHEMVCQLITNILD 159

  Fly   125 DAAVKDLLNSGEKFDLVIMEAVQTEALFG------------LIQHFGAETIGISSYGTDTHIDEL 177
            ...:..:||. :::||::     |:.::|            ::.:....|.|      :.|.|..
Zfish   160 SEEILKMLNE-KQYDLML-----TDPVWGTGIILAHKLKLPMVYNVRWTTTG------EGHFDIA 212

  Fly   178 MGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDE 242
            .   ||:||.|:..|..|::|.|..|:.|.|...::.|.....::...:.:..||| |:|.:..|
Zfish   213 P---SPMSYIPITGSGNTDRMSFFQRLKNYFFYLLLDLQLSHFNVKQYQAICDKYF-TSRVNFHE 273

  Fly   243 VLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMG 306
            :|....|.|:...|...:|||.:||:|.:||.   |....:||..:|.:|::.| :.|||..|:|
Zfish   274 LLQGADLWLMRVDFVFEFPRPTMPNIIYIGGF---QCPPAKPLPHDLEDFMQSSGDHGVIVMSLG 335

  Fly   307 SNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFIT 371
            |.|  .:||.:....:...||.:||:|:|::...:.....:|..:..|.||.|:|.||..|:||:
Zfish   336 SLI--GNLPENVTAEIAAAFARLPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLLGHPKTKVFIS 398

  Fly   372 HGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSY 436
            |||....:|::|.|.|::|:|.|:||:.|:.|.:..|......|..:....|...|||:::.|||
Zfish   399 HGGTNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTLHAAIQEVINEPSY 463

  Fly   437 AAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFV 501
            .......|.|.:|:....|:.||:|.|:|:|||||.|||..|..:.:..:|.:|     :.:|..
Zfish   464 RLNMHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVD-----VVVTLF 523

  Fly   502 SLLIVVILIKCLQRVFVSL 520
            :  :|:||..|   :||::
Zfish   524 A--VVLILTYC---IFVTV 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	143/489 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	146/501 (29%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	154/528 (29%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	85/251 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585088
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690