Protein Alignment Ugt35A1 and UGT2B17

DIOPT Version :9

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 159/534 - (29%)
• Similarity: 263/534 - (49%)
• Gaps: 84/534 - (15%)

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEI------------------M 90
            |.:|..:..::||..|||.|.|:.:..|       .::.|.|...|                  |
Human    34 SHWINMKTILEELVQRGHEVIVLTSSAS-------ILVNASKSSAIKLEVYPTSLTKNDLEDFFM 91

  Fly    91 AAFGNADYTQTASQ-WQMLTMTTQF--------LNLLTTSILDDAAVKDLLNSGEKFDLVIMEAV 146
            ..|....|:.:.:. |...:...:.        :.|...::|:...::.|..|  |||:::.:||
Human    92 KMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQES--KFDVLLADAV 154

  Fly   147 QT--EALFGLIQHFGAETIGIS-----SYGTDTHIDELMGN-ISPLSYNPLLLSSRTEQMDFKDR 203
            ..  |.|        ||.:.|.     .:.....:::..|. :.|.||.|:::|..::||.|.:|
Human   155 NPCGELL--------AELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMER 211

  Fly   204 VMNV-----FEASVMWLHKRIVHLPSQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYP 261
            :.|:     |:   .|.  :...|......|::..  ||   :|.|.:....:.|:..::...:|
Human   212 IKNMIYMLYFD---FWF--QAYDLKKWDQFYSEVLGRPT---TLFETMGKAEMWLIRTYWDFEFP 268

  Fly   262 RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQT 325
            ||:|||:..|||||.   :..:||.||:.|||:.| |.|::.||:||.|  .::...:..|:...
Human   269 RPFLPNVDFVGGLHC---KPAKPLPKEMEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASA 328

  Fly   326 FASVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGK 386
            .|.:||:|||:|:.    :||:    |..:.||.||.|:|.||..|.||||||.....|:||.|.
Human   329 LAQIPQKVLWRFDG----KKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGI 389

  Fly   387 PILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQK 451
            |::|:|:|.|||.|:...|..|..||.||.::::.:|...::.::::|.|.......|::..||.
Human   390 PMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQP 454

  Fly   452 ETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRV 516
            ...|:||::|.|:|:|||||||||.|:.:|.:||:|.||....|:|.  |:.:|.:| .||....
Human   455 VKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLAC--VATMIFMI-TKCCLFC 516

  Fly   517 FVSLISKIRKNRAE 530
            |..|....:|.:.:
Human   517 FRKLAKTGKKKKRD 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	139/476 (29%)
		UDPGT	55..526	CDD:278624	156/517 (30%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	156/520 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150257
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690