DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and UGT2B15

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001067.2	Gene:	UGT2B15 / 7366	HGNCID:	12546	Length:	530	Species:	Homo sapiens

Alignment Length:	561	Identity:	168/561 - (29%)
Similarity:	273/561 - (48%)	Gaps:	83/561 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPN 77
            |||.|...|::.:     ..::| |:| ...|.:|..:..::||..|||.|||:.:..|
Human    10 LLIQLSCYFSSGS-----CGKVL-VWP-TEYSHWINMKTILEELVQRGHEVTVLTSSAS------ 61

  Fly    78 FRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFL--------------------------- 115
             .::.|.|...|.........|:...:..:|.:..:::
Human    62 -TLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSN 125

  Fly   116 NLLTTSILDDAAVKDLLNSGEKFDLVIMEAVQT--EALFGLIQHFGAETIGIS-------SYGTD 171
            .|...::|:...:..|..|  |||:::.:|:..  |.|        ||...|.       |.|.
Human   126 KLCKDAVLNKKLMMKLQES--KFDVILADALNPCGELL--------AELFNIPFLYSLRFSVGY- 179

  Fly   172 THIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYF--P 234
            |......|.:.|.||.|:::|..::||.|.:|:.|:..........:|..|......|::..  |
Human   180 TFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRP 244

  Fly   235 TARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EK 298
            |   :|.|.:....:.|:..::...:|||:|||:..|||||.   :..:||.||:.|||:.| |.
Human   245 T---TLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC---KPAKPLPKEMEEFVQSSGEN 303

  Fly   299 GVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPD 359
            |::.||:||.|  .::...:..|:....|.:||:|||:|:.    :||:    |..:.||.||.|
Human   304 GIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFDG----KKPNTLGSNTRLYKWLPQND 362

  Fly   360 ILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELT 424
            :|.||..|.||||||.....|:||.|.|::|:|:|.|||.|:...|..|..||.||.::::.:|.
Human   363 LLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLL 427

  Fly   425 PLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGL 489
            ..::.::::|.|.......|::..||....|:||::|.|:|:|||||||||.|:.:|.:||:|.|
Human   428 NALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSL 492

  Fly   490 DTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            |....|:|.  |:.:|.:|...|| ..|..|..|.:|.:.:
Human   493 DVIAFLLAC--VATVIFIITKFCL-FCFRKLAKKGKKKKRD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	143/497 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	157/513 (31%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	161/536 (30%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	159/528 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150281
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690