DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and UGT2B7

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001065.2	Gene:	UGT2B7 / 7364	HGNCID:	12554	Length:	529	Species:	Homo sapiens

Alignment Length:	549	Identity:	164/549 - (29%)
Similarity:	266/549 - (48%)	Gaps:	62/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRIL---AVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDK 73
            ||||.|.:.|::.     ...::|   |.:     |.::..:..:.||..|||.|||:.:..|..
Human     9 ILLIQLSFCFSSG-----NCGKVLVWAAEY-----SHWMNIKTILDELIQRGHEVTVLASSASIL 63

  Fly    74 NEPNFRVIGAKKIHEIMAAFGNAD----YTQTASQWQMLTMTTQFLNLLTT----SILDDAA--- 127
            .:||..  .|.||.....:....:    ..|...:|..|...|.:|.....    ||..|..
Human    64 FDPNNS--SALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKF 126

  Fly   128 VKDLLNSGE--------KFDLVIMEAV--QTEALFGLIQHFGAETIGIS-SYGTDTHIDELMGNI 181
            .||::::.:        :||::..:|:  .:|.|..|.......::..| .|..:.|..   |.|
Human   127 CKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSG---GFI 188

  Fly   182 SPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYF--PTARKSLDEVL 244
            .|.||.|:::|..|:||.|.:||.|:...........|..:......|::..  ||   :|.|.:
Human   189 FPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPT---TLSETM 250

  Fly   245 DSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSN 308
            ....:.|:...::..:|.|.|||:..|||||.   :..:||.||:.:||:.| |.||:.||:||.
Human   251 GKADVWLIRNSWNFQFPYPLLPNVDFVGGLHC---KPAKPLPKEMEDFVQSSGENGVVVFSLGSM 312

  Fly   309 IKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPDILAHPNVKLF 369
            :  .::......::....|.:||:|||:|:.:    |||    |..:.||.||.|:|.||..:.|
Human   313 V--SNMTEERANVIASALAQIPQKVLWRFDGN----KPDTLGLNTRLYKWIPQNDLLGHPKTRAF 371

  Fly   370 ITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNP 434
            |||||.....|:||.|.|::|:|:|.||..|:...|..|..:..|..::::|:|...::.::::|
Human   372 ITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDP 436

  Fly   435 SYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAIT 499
            ||.......|::..||....|:||::|.|:|:|||||||||.|:.||.:.|:|.||..|.|:...
Human   437 SYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCV 501

  Fly   500 FVSLLIVVILIKCLQRVFVSLISKIRKNR 528
               ..::.|:.||....|.....|.:|.:
Human   502 ---ATVIFIVTKCCLFCFWKFARKAKKGK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	141/486 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	154/499 (31%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	157/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150435
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690