Protein Alignment Ugt35A1 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 171/544 - (31%)
• Similarity: 271/544 - (49%)
• Gaps: 82/544 - (15%)

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFP--FPGRSQYIFAEQFMKELAHRGHNVTVINTFGS--- 71
            :|||.|...|::.:     ..::| |:|  |   |.::..:..:.||..|||.|||:.:..|
Human     9 LLLIQLSCYFSSGS-----CGKVL-VWPTEF---SHWMNIKTILDELVQRGHEVTVLASSASISF 64

  Fly    72 DKNEPN---FRVIGA-----------KKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSI 122
            |.|.|:   |.|...           |::.:..|......:....||.|.:..|  |.::|....
Human    65 DPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWT--FNDILRKFC 127

  Fly   123 LDDAAVKDLLN--SGEKFDLVIMEAVQTEALFGLIQHFGAETIGI---------SSYGTDTHIDE 176
            .|..:.|.|:.  ...:||:|:.:||..   ||.:.   ||.:.|         ..|..:.|..
Human   128 KDIVSNKKLMKKLQESRFDVVLADAVFP---FGELL---AELLKIPFVYSLRFSPGYAIEKHSG- 185

  Fly   177 LMGNISPLSYNPLLLSSRTEQMDFKDRVMNV-----FEASVMWLHKRIVHLPSQRDLYAKYF--P 234
              |.:.|.||.|:::|..::||.|.:||.|:     ||   .|.  :|..:......|::..  |
Human   186 --GLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFE---FWF--QIFDMKKWDQFYSEVLGRP 243

  Fly   235 TARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EK 298
            |   :|.|.:....:.|:..::...:|.|.|||:..|||||.   :..:||.||:.|||:.| |.
Human   244 T---TLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHC---KPAKPLPKEMEEFVQSSGEN 302

  Fly   299 GVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPD 359
            ||:.||:||.:.:..  .....::....|.:||:|||:|:.:    |||    |..:.||.||.|
Human   303 GVVVFSLGSMVSNTS--EERANVIASALAKIPQKVLWRFDGN----KPDTLGLNTRLYKWIPQND 361

  Fly   360 ILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELT 424
            :|.||..:.||||||.....|:||.|.|::|:|:|.||..|:...|..|..:|.|..::::|:|.
Human   362 LLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLL 426

  Fly   425 PLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGL 489
            ..::.::::|.|...|...|::..||....|:||::|.|:|:|||||||||.|:.||.:.|:|.|
Human   427 NALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSL 491

  Fly   490 DTWGLLIAITFVSLLIVVILIKCL 513
            |..|.|:|..   ..::.|:.|||
Human   492 DVTGFLLACV---ATVIFIITKCL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	150/496 (30%)
		UDPGT	55..526	CDD:278624	161/499 (32%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	169/542 (31%)
		UDPGT	24..524	CDD:278624	166/524 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150436
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690