DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	537	Identity:	161/537 - (29%)
Similarity:	267/537 - (49%)	Gaps:	67/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKI---------- 86
            |::| |:|. ..|.::..:..::||..|||.|||:       ..|:..:..:|:|
Mouse    24 SKVL-VWPC-DMSHWLNLKTILEELGARGHEVTVL-------KYPSIIIDQSKRIPLHFENIPLL 79

  Fly    87 HEIMAAFGN--------ADYTQTASQWQML-TMTTQFLNL------LTTSILDDAAVKDLLNSGE 136
            :||..|...        .:.....|.|:.. |:...||.:      :..|:|.:....|.|...:
Mouse    80 YEIETAENRLNEIANLAVNVIPNLSLWEAAKTLQDFFLQVTGDFESICRSVLYNQKFMDKLRDAQ 144

  Fly   137 KFDLVIMEAVQT--EALFGLIQHFGAETIGIS-SYGTDTHIDELMGNISPLSYNPLLLSSRTEQM 198
             :|:|:::.|..  |.:..::|.....|:..| .|..:.|..:|.   .||||.|:::|..|:.|
Mouse   145 -YDVVVIDPVVPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQLP---IPLSYVPVVMSELTDNM 205

  Fly   199 DFKDRVMN-----VFEASVMWLHKRIVHLPSQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHF 256
            .|.:||.|     :||   .||.:.......|  .|::..  ||   :..:.:....:.|:..::
Mouse   206 TFTERVKNMMFSLLFE---YWLQQYDFAFWDQ--FYSETLGRPT---TFCKTVGKADIWLIRTYW 262

  Fly   257 SLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRK 320
            .:.:|||||||...|||||.   :..:||.||:.|||:.| |.||:.||:||.:  |:|......
Mouse   263 DVEFPRPYLPNFEFVGGLHC---KPAKPLPKEMEEFVQSSGEHGVVVFSLGSMV--KNLTEEKAN 322

  Fly   321 MLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFG 385
            ::....|.:||:|||::...:......|..:..|.||.|:|.||..|.||||||.....|:||.|
Mouse   323 LIASVLAQIPQKVLWRYSGKKPATLGSNTRLFNWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 387

  Fly   386 KPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQ 450
            .|::|:|:..||..|:...:..|..|...|.::.:|:|...::.:::.|||...|...|::..||
Mouse   388 VPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINEPSYKENAMRLSRIHHDQ 452

  Fly   451 KETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWG-LLIAITFVSLLIVVILIKCLQ 514
            ....|:||::|.|:|:|||||||||.|:.||.:.|:|.||..| ||:.:..::.:|....:...|
Mouse   453 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLLCVVTLTFIITKFCLFVCQ 517

  Fly   515 RVFVSLISKI----RKN 527
            ::::....|:    :||
Mouse   518 KLYMKESKKMGNRKKKN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	143/477 (30%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	154/511 (30%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	157/526 (30%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	96/243 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840281
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.690