DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	515	Identity:	155/515 - (30%)
Similarity:	250/515 - (48%)	Gaps:	82/515 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFG------SDKNEPNFRVIGAK-KIHEIMAAF----GNAD 97
            |.:|..:..:.||..|||:|||:.:..      |:::..||.:..|. ...::..||    ||..
Mouse    34 SHWINMKIILDELVQRGHDVTVLISSASILIGPSNESSINFEIYSAPLSKDDLEYAFEKWVGNWT 98

  Fly    98 YTQTASQWQMLTMTTQFLNLLTTSILDDAAVKDLLNS----------------GEKFDLVIMEA- 145
            |     :.:.|...|.:..|...|    :...|::.|                |.|||:|:.:|
Mouse    99 Y-----ELKKLPFWTSYSKLQKIS----SEYSDMIESFCKAVVWNKSLMKKLQGSKFDVVLADAL 154

  Fly   146 ----------VQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNIS-PLSYNPLLLSSRTEQMD 199
                      ::|..::.|            .:......::..|.:. |.||.|::||..::.|.
Mouse   155 VPCGELLSELLKTPLVYSL------------RFCPGYKCEKYSGGLPLPPSYVPVVLSELSDHMT 207

  Fly   200 FKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYPR 262
            |.:||.|:.:..:.....:..:..|....|:...  ||   :|.|::....:.|:...:.|.:|.
Mouse   208 FAERVKNMLQVLLFDFWFQTFNEKSWNQFYSDVLGRPT---TLTEMMGKADIWLVRTFWDLKFPH 269

  Fly   263 PYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTF 326
            |:|||...|||||.   :..:||.||:.|||:.| |.||:.||:||.:  |::......::....
Mouse   270 PFLPNFDFVGGLHC---KPAKPLPKEMEEFVQSSGEHGVVVFSLGSMV--KNIKEEKANVVASAL 329

  Fly   327 ASVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKP 387
            |.:||:|||:|:.    :|||    |..:.||.||.|:|.||..|.||.|||.....|:||.|.|
Mouse   330 AQIPQKVLWRFDG----KKPDTLGSNTRLYKWIPQNDLLGHPKTKAFIAHGGTNGIYEAIYHGIP 390

  Fly   388 ILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKE 452
            |:|:|:|.||..|:......|..:..|..:::.|:|...::.::::|||...|...|::..||..
Mouse   391 IVGIPLFGDQPDNINHIVAKGAAVRVDFDTMSTTDLLTALKTVINDPSYKENAMRLSRIHHDQPM 455

  Fly   453 TALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKC 512
            ..|:||::|.|||:|:|||||||.|..||.:.|:|.||..|.|:...   :.:|.|:.||
Mouse   456 KPLDRAVFWIEYVMRNKGAKHLRPALHDLTWFQYHSLDVIGFLLVCV---VAVVFIIAKC 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	139/475 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	153/504 (30%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	152/509 (30%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	155/515 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840434
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690