DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	557	Identity:	155/557 - (27%)
Similarity:	243/557 - (43%)	Gaps:	130/557 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI---------------------NTFGS 71
            |....::| |||..| |.::..:..::||..:||||||:                     ||.|.
Zfish    18 GTYGGKVL-VFPLDG-SHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEESPFYSSITIPNTGGF 80

  Fly    72 DK-------------NEPNFRVIGAKKIH-EIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSI 122
            |:             ....:.|:...::. |||..|              .||....|.::...:
Zfish    81 DEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKF--------------KTMHEDMLQMMDRML 131

  Fly   123 LDDAAVKDLLNSGEKFDLVIME-----------------------AVQTEALFGLIQHFGAETIG 164
            .|:..:..:.::  |||:|:.:                       .:|.|..|.:..
Zfish   132 EDEKVMNSIQDA--KFDVVLADPAVGGGPILAYKFNIPLVFNVRWTIQGEGHFAIAP-------- 186

  Fly   165 ISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLY 229
                             |||||.|:.....|::|.|..||.||           :::|.||..:.
Zfish   187 -----------------SPLSYIPVPGVELTDKMSFLQRVKNV-----------LIYLISQIQMQ 223

  Fly   230 AK----YFPTARKSLDEVLDSFALM------LLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQP 284
            ..    |.|...|.....:..|:|.      |:...|:..:|||.:||::.:.|.   |.:..:|
Zfish   224 IMVEPIYAPFCHKHFGPNVTYFSLFQDADIWLMRNDFTFEFPRPTMPNIVYMSGF---QCKPAKP 285

  Fly   285 LAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDN 348
            |..:|.:|||.| |.|||..|:|:.|  ..||......:...||.:||:|:|::...:.....:|
Zfish   286 LPNDLEKFVESSGEHGVIVMSLGTLI--AQLPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGNN 348

  Fly   349 VFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSA 413
            ..:.:|.||.|:|.||.:|:|:.|||.....|:||.|.||||||:.:||..|:.|.:..|.....
Zfish   349 TLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIV 413

  Fly   414 DIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCAS 478
            ||.:::.|.....::|:|.||||....|..|||..||....|:||::|.|:|:|:|||.|||..|
Zfish   414 DIATLDKTVFLEALKEVLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQS 478

  Fly   479 RDLDFIQFHGLDTWGLLIAITFVSLLIVVILIK--CL 513
            ..:.:|::|.:|....|:...||..|::...||  ||
Zfish   479 FRMSWIEYHSIDVILTLMVTGFVFALMIGYTIKYFCL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	140/514 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	148/530 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	154/553 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584436
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690