DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt5g1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001107914.1	Gene:	ugt5g1 / 570913	ZFINID:	ZDB-GENE-080305-10	Length:	528	Species:	Danio rerio

Alignment Length:	532	Identity:	148/532 - (27%)
Similarity:	252/532 - (47%)	Gaps:	65/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGS---------------------DKNEPNF 78
            :.|||..| |.::..:..:::|...||:.||:.:..|                     |..:..|
Zfish    26 ILVFPEDG-SHWVNMQVILRKLHTHGHSFTVVRSSKSWYIHENSALYNTITVNPVETEDVGQDYF 89

  Fly    79 -----RVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLN---LLTTSILDDA-AVKDLLNS 134
                 |.:..:|:..::..|        ..|..:.|:...|.|   .:.:::|||| .||.|..:
Zfish    90 NMLLDRSLALQKMSPLVRFF--------EQQKDITTVLKVFHNGVLRMVSAMLDDAELVKSLREA 146

  Fly   135 GEKFDLVIME-----AVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSR 194
              ||||::.:     .|.......|...:....:...    |.|:....   ||.||.|:..|..
Zfish   147 --KFDLLLTDPAFPAGVLVANFLQLPMVYNVRWLNAG----DAHMQTAP---SPPSYVPMYNSLL 202

  Fly   195 TEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLS 259
            .:||.|..||.|........|.:|.|.:|..|:|..::||.. ..|..:..|..:.|:...|...
Zfish   203 HDQMSFLQRVENFLRYLCSLLQERYVIVPIYRELLERHFPPG-SDLLSMQQSADIWLMRMDFVFD 266

  Fly   260 YPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLM 323
            :|||.:||:|.:||.   |.:..|.|..:|.||::.| |.||::.|:|:.:.:  ||.:..:.:.
Zfish   267 FPRPTMPNIIYMGGF---QCKPAQALPVDLEEFMQSSGEHGVVFMSLGAMVGA--LPRTITEAIA 326

  Fly   324 QTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPI 388
            ..||.:||:|:|::..::.....:|..:.:||||.|:|.||..:.|::|||.....|:||.|.|:
Zfish   327 SAFAKIPQKVMWRYHGERPSTLGNNTLLLEWFPQNDLLGHPKTRAFVSHGGTNGIYEAIYHGVPV 391

  Fly   389 LGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKET 453
            |.||:.:||..||.|.:.........:.::.:.|....::::|.||.|.::.:..|:|.|||..:
Zfish   392 LALPLLFDQFDNVMRLQVRNAARVLQVATLTSQEFLEGLKDVLENPLYRSSIRKMSELHRDQPIS 456

  Fly   454 ALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFV 518
            .|:.|.:|.|||:|||||.|||..:.:|.:..:|.||....|:||..::....|.:.:     |:
Zfish   457 PLDSATFWIEYVMRHKGAAHLRSEANNLAWYSYHSLDVLVFLLAIAVIAFWTSVYVCR-----FL 516

  Fly   519 SLISKIRKNRAE 530
            .....|:|.:.:
Zfish   517 CCRKSIKKRKVD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	134/474 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	142/506 (28%)
ugt5g1	NP_001107914.1	UDPGT	24..526	CDD:278624	148/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584627
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790