Protein Alignment Ugt35A1 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 152/561 - (27%)
• Similarity: 254/561 - (45%)
• Gaps: 73/561 - (13%)

  Fly     8 TGLGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVIN-TFGS 71
            |||.:||....|         .:|.::|.| |..| |.::...:.::||..|||...|:. ....
Human    14 TGLLLLLSVQPW---------AESGKVLVV-PTDG-SPWLSMREALRELHARGHQAVVLTPEVNM 67

  Fly    72 DKNEPNFRVIGAKKIHEIMAAFGNA--DYTQ-----------TASQWQMLTMTTQFLNLLTTSIL 123
            ...|..|..:.|..:......|...  .|||           .:....::...:..|:.....:|
Human    68 HIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELL 132

  Fly   124 DDAAVKDLLNSGEKFDLVIMEAVQTEALFG--LIQHFGAETIGISSY--------GTDTHIDELM 178
            .:.|:...||: ..||:|:.:.|.   |.|  |.::.....:....|        ||...
Human   133 HNEALIRHLNA-TSFDVVLTDPVN---LCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCP----- 188

  Fly   179 GNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARK----- 238
               :|.||.|.||::.::.|.|..||.|:.....:   ..|.|..|     |.|...|.:
Human   189 ---NPSSYIPKLLTTNSDHMTFLQRVKNMLYPLAL---SYICHTFS-----APYASLASELFQRE 242

  Fly   239 -SLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVI 301
             |:.:::...::.|....|.:.||||.:|||:.:||::....:   ||::|...::..| |.|::
Human   243 VSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGK---PLSQEFEAYINASGEHGIV 304

  Fly   302 YFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNV 366
            .||:||.:  .::|......:......:||.|||::...:.....:|..:.||.||.|:|.||..
Human   305 VFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMT 367

  Fly   367 KLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELL 431
            :.||||.|.....|||..|.|::.:|:|.||..|.:|.:..|.|::.::..:.:.:|...::.::
Human   368 RAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVI 432

  Fly   432 SNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLI 496
            ::.||.......|.|.:|:....|:.|::|.|:|:|||||.|||.|:.||.:.|:|.||..|.|:
Human   433 NDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL 497

  Fly   497 AITFVSLLIVVILIKCLQRVFVSLISKIRKNRA-EASKLKT 536
            |:.   |.:..|..||....:...:.|  |.|. :|.|.||
Human   498 AVV---LTVAFITFKCCAYGYRKCLGK--KGRVKKAHKSKT 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	123/485 (25%)
		UDPGT	55..526	CDD:278624	134/501 (27%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	140/527 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150584
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690