Protein Alignment Ugt35A1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 159/547 - (29%)
• Similarity: 257/547 - (46%)
• Gaps: 90/547 - (16%)

  Fly    35 LAVFPFPGRSQYIFAEQFMKELAHRGHNVTV----------------INTFGS-----DKNEPNF 78
            |.|.|..| |.:...:..:::|..|||.|.|                :.|:.:     |:|
Human    28 LLVVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQN---- 87

  Fly    79 RVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQ--FLNLLTT---SILDDAAVKDLLNSGEKF 138
                    .|.| .|.:|.:...|.....|.|::.  ||:|..:   |:.:|..:.:.|.. ..|
Human    88 --------REFM-VFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKE-SSF 142

  Fly   139 DLVIMEAVQTEALFGLI--QHFGAETI----GISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQ 197
            |.|.::...|   .|||  ::|...::    ||..:    |::|.....:||||.|..|...::.
Human   143 DAVFLDPFDT---CGLIVAKYFSLPSVVFTRGIFCH----HLEEGAQCPAPLSYVPNDLLGFSDA 200

  Fly   198 MDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKY-FPTARKSLDEVLDS----------FALML 251
            |.||:||         |.|  ||||  :..|:.:| |..|.:...|:|.:          .::.|
Human   201 MTFKERV---------WNH--IVHL--EDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWL 252

  Fly   252 LGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLP 315
            |...|.|.||:|.:||||.:||::..|.:   ||..|...::..| |.|::.||:||.:  .::|
Human   253 LRTDFVLDYPKPVMPNMIFIGGINCHQGK---PLPMEFEAYINASGEHGIVVFSLGSMV--SEIP 312

  Fly   316 PSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIE 380
            ......:......:||.|||::...:.....:|..:.||.||.|:|.||..:.||||.|.....|
Human   313 EKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYE 377

  Fly   381 SIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSK 445
            ||..|.|::.:|:|.||..|.:|.:..|.|::.::..:.:.:|...::.::::.||.......|.
Human   378 SICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSS 442

  Fly   446 LFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILI 510
            |.:|:....|:.|::|.|:|:|||||.|||.|:.||.:.|:|.||..|.|:|:.   |.:..|..
Human   443 LHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV---LTVAFITF 504

  Fly   511 KCLQRVFVSLISKIRKNRA-EASKLKT 536
            ||....:...:.|  |.|. :|.|.||
Human   505 KCCAYGYRKCLGK--KGRVKKAHKSKT 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	Glycosyltransferase_GTB-type	19..474	CDD:471961	135/482 (28%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	154/537 (29%)