DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and UGT2B28

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_444267.1	Gene:	UGT2B28 / 54490	HGNCID:	13479	Length:	529	Species:	Homo sapiens

Alignment Length:	499	Identity:	154/499 - (30%)
Similarity:	244/499 - (48%)	Gaps:	48/499 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHE-----------IMAAFGNAD 97
            |.::..:..:|||..|||.|||:.:..|...:||.......:::.           ||.......
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWS 98

  Fly    98 YTQTASQWQMLTMTTQ--------FLNLLTTSILDDAAVKDLLNSGEKFDLVIMEAVQT--EALF 152
            ..|..|.|...:...:        |.|.....:.:...:|.|..|  :||::..:|...  |.|.
Human    99 DIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQES--RFDIIFADAFFPCGELLA 161

  Fly   153 GLIQ-HFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLH 216
            .|:. .|.........|..:.|..   |.|.|.||.|:::|..::||.|.:||.|:.........
Human   162 ALLNIPFVYSLCFTPGYTIERHSG---GLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFW 223

  Fly   217 KRIVHLPSQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQK 279
            .::..:......|::..  ||   :|.|.:....:.|:...:|..:|.|:|||:..|||||.
Human   224 FQMCDMKKWDQFYSEVLGRPT---TLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHC--- 282

  Fly   280 RKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLP 343
            :..:||.||:.|||:.| |.||:.||:||.|  .::......::....|.:||:|||:|:.:
Human   283 KPAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDGN--- 342

  Fly   344 EKPD----NVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRA 404
             |||    |..:.||.||.|:|..|..:.||||||.....|:||.|.|::|:|:|:||..|:...
Human   343 -KPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHM 406

  Fly   405 KQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHK 469
            |..|..:..|..::::|:|...::.::::|||.......|.:..||....|.||::|.|:|:.||
Human   407 KAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHK 471

  Fly   470 GAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCL 513
            ||||||.|:|||.:.|:|.||..|.|:|.  |:.:|.|:...||
Human   472 GAKHLRVAARDLTWFQYHSLDVIGFLLAC--VATVIFVVTKFCL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	135/458 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	152/488 (31%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	154/499 (31%)
UGT2B28	NP_444267.1	egt	<269..506	CDD:223071	97/247 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150489
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690