DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	164/536 - (30%)
Similarity:	263/536 - (49%)	Gaps:	40/536 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEP 76
            :||:|::        ...|.:.||.:|.....|..|......|.|...||||||::..     :|
  Fly     9 LLLLGVV--------ASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSML-----KP 60

  Fly    77 NFRVIGAKKIHEIMAAFGNA-------DYTQTASQWQMLTMTTQFLNLLTTSILDDAAVKDLLNS 134
            .   :..|.||.|:......       ..|:.|.|...|..|  ...|||:..:...|..:||:.
  Fly    61 K---VTHKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVST--MYRLLTSMDVMINAQAELLSD 120

  Fly   135 GE-------KFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLS 192
            ..       ||||:|:.....:...|:........|..........||:..||.|.|||.||:.:
  Fly   121 PRFQRIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMGT 185

  Fly   193 SRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTA-RKSLDEVLDSFALMLLGQHF 256
            ..|:.|.|..|..|..: |:::....:|.......:|...||.. ..:|.|:..:.::..:|.|.
  Fly   186 VATQPMGFLKRTENALK-SLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMAFVGSHL 249

  Fly   257 SLSYP-RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRK 320
            ....| ||.:|.:||:||  :|.|.|..||.|::.:|:..:::|.::.|:|||:||..:.|...:
  Fly   250 ISEGPIRPLVPALIEIGG--IQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPEIVQ 312

  Fly   321 MLMQTFASVPQRVLWKFED-DQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYF 384
            ::.:..:.:.:.|:||:|| :..|....|:....|.||.|||||||.||||||.|.....|:.|.
  Fly   313 IIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYH 377

  Fly   385 GKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRD 449
            |.|::.||||.||..|....::.||||:.|:.|:....|...::|:|.|..|..|....|.|:||
  Fly   378 GVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRD 442

  Fly   450 QKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQ 514
            :..||.:..::||||:|||:||.:|:..|..::|||.:.||.:.|::.|..:.:|:..::.|.:.
  Fly   443 RPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLTRLVAKIVW 507

  Fly   515 RVF--VSLISKIRKNR 528
            ..|  .:.||:.:|.:
  Fly   508 NKFGGKAKISQTKKKQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	146/471 (31%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	153/489 (31%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	149/478 (31%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	154/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445682
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850