DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt37D1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	175/560 - (31%)
Similarity:	274/560 - (48%)	Gaps:	61/560 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKN 74
            ||.||:.|:.|  ....:|.:.:.||.||.....|.:|.....||.||.:||||||:::.
  Fly    13 LGGLLVALLAL--QTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSV----- 70

  Fly    75 EPNFRVIGAKKIHEIMAAFGNAD-----------YTQTASQWQMLTMTTQFLNLL---TTSILDD 125
            .|.   :..|.|:.|:......|           ..:..|.|..:......|.||   ...:|:|
  Fly    71 PPK---VTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLED 132

  Fly   126 AAVKDL-LNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTD-THIDELMGNISPLSYNP 188
            ...::| ||.|.|||:|.:..........|...|....| ||..|.. ..::|::||....|...
  Fly   133 PRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVI-ISWSGPPMMMVNEVLGNPELSSVPQ 196

  Fly   189 LLLSSRTEQ-MDFKDRVMNV-----FEASVMWL-HKRIVHLPSQRDLYAKYFPTARKSLDEVLDS 246
            :.:|:...| |:|:.|:.|.     |.|..::| ||           |.|::... .|.|:.:.:
  Fly   197 MHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHK-----------YNKFYDRL-WSKDKSMPT 249

  Fly   247 FA-------LMLLGQHFSLSYP-RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYF 303
            ||       |.....|.....| ||.:|.:||:||  :|.|.|..||.:::.||:|:.:.|.|.|
  Fly   250 FAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGG--IQVKSKPDPLPEDIQEFLEKGKHGAILF 312

  Fly   304 SMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQ-LPEKPDNVFISKWFPQPDILAHPNVK 367
            |:|||:|.:.:.|...|.:.:..:|:.|:|:||:||.: .|.|..|:...||.||.||||||.:|
  Fly   313 SLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLK 377

  Fly   368 LFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLS 432
            |||||.|.....|:.|.|.|:|.||:|.||..|..:....||||...:.:::..|....|:|::.
  Fly   378 LFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIE 442

  Fly   433 NPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIA 497
            ||.||...::.|:|:||:..:..|..::|||||:||.||.|::.....::||..:.||.:.:...
  Fly   443 NPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDIYIIAAL 507

  Fly   498 ITFVSLLIVVILIKCLQRVFVSLISKIRKNRAEASKLKTQ 537
            :.::..:|..|:.|.:.|......:|:.|.:    |:|.|
  Fly   508 VLYIVFIINKIVWKFVWRKLFGKSNKVSKGK----KVKKQ 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	156/486 (32%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	156/502 (31%)
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	160/509 (31%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	159/507 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445696
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950