DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	224/531 - (42%)
Similarity:	319/531 - (60%)	Gaps:	24/531 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNE 75
            |.|.:.|..|.:.     |.:...|.|.....||.|.......|.||..||.||:|:.|...|..
  Fly     9 GFLALLLFCLLSC-----VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPI 68

  Fly    76 PNFRVIGAKKIHEIMAAFGN-ADYTQTASQWQMLTMTTQFLNL------LTTSILDDAAVKDLLN 133
            .|.:.:.||.|  :.:..|. |:..|::.:    .:..|.:|.      :|..:|.:.:|.:|:.
  Fly    69 KNIKDVPAKSI--LTSMQGRIANLLQSSKE----PIIKQIINFHEMGIEITELLLKEPSVIELMK 127

  Fly   134 SGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQM 198
            |.:.||.||.|....||.||..:||.|..||:.::|..:...:|:|:.||.||.|..|...:::|
  Fly   128 SNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPSALLKFSDRM 192

  Fly   199 DFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRP 263
            ...:||.|....:..::.....:||.|..||.||||..::...::..:.||:||.||.|||:|||
  Fly   193 SLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSLSFPRP 257

  Fly   264 YLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFAS 328
            |.||||||||:|:.:||  |||.|::.||:|.:|.||||||||||:|||.||...|:.|:.|||.
  Fly   258 YSPNMIEVGGMHINRKR--QPLPKDILEFIEGAEHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQ 320

  Fly   329 VPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPI 393
            :.|||||||||..||.||.|||||.||||.|||||.||..||||||||||.||||..||.:|:||
  Fly   321 LKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPI 385

  Fly   394 FYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERA 458
            |.||.||:.||:|.|||::.....:::.:|...||::::||......:..|..:|||::|.||||
  Fly   386 FGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERA 450

  Fly   459 IWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDT----WGLLIAITFVSLLIVVILIKCLQRVFVS 519
            ::|.|:|.||||||:||.||:||:|||:|.||.    :|.:|.:.:...|::.::.:.||.:|:.
  Fly   451 VYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRLVWRLLQELFIK 515

  Fly   520 LISKIRKNRAE 530
            ..:...|.:|:
  Fly   516 KDTSKPKQKAK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	201/461 (44%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	211/481 (44%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	174/350 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445604
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.810