DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	199/526 - (37%)
Similarity:	301/526 - (57%)	Gaps:	21/526 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEP 76
            :.|.|..|.::           .|.:.....:|.|.......|.||..||.||:::.|...|...
  Fly    13 LALFGQSWGYS-----------YLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRKPIK 66

  Fly    77 NFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTM-TTQFLNL-LTTSILDDAAVKDLLNSGEKFD 139
            |...:....|..:|..: .|...:.|.:..:|.. ....:.| :|.|:|.:..|::||.....||
  Fly    67 NIIDVETPNIITVMGVY-KARILENAKKPVLLRYPRISLMGLDITESLLKEPKVQELLKQNRTFD 130

  Fly   140 LVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRV 204
            .||.|....:|.:|..:||||..|.:||.|......:|:|..||.||.|..|....::|:|.:|.
  Fly   131 GVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDRMNFWERA 195

  Fly   205 MNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMI 269
            .|:......:.::.:::||....||.||||..::....:....:|:||..|.|:|.||||.||||
  Fly   196 QNLGFQIYEFAYENLINLPRHEALYRKYFPNNKQDFYRMRKDTSLVLLNNHVSISNPRPYSPNMI 260

  Fly   270 EVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVL 334
            ||||:|:.:|.. :||.:.:.:|:|::|.||||||:|||:.|||||.:.||.:::|...:..||:
  Fly   261 EVGGMHVNRKAP-KPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRKAIVETLRGLKYRVI 324

  Fly   335 WKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHL 399
            ||:|::...:|||||.||.|.||.|||||..|..||||||||||:||||.|||::|:|.|.||.:
  Fly   325 WKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGKPVVGIPFFGDQFM 389

  Fly   400 NVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEY 464
            |:.||:|:|||::.....:.|:.....|:.:.|:||:....:..|..:||||||.||||::|.|:
  Fly   390 NMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQKETPLERAVYWVEH 454

  Fly   465 VLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRA 529
            |.||||||:||.|.:||:|||:|.||......::..::::.|.:|::.|..:....:.|
  Fly   455 VTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVRFLVTIVNGFLYK------ 513

  Fly   530 EASKLK 535
            .:||||
  Fly   514 PSSKLK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	178/456 (39%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	188/472 (40%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	156/350 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445605
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.810