DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	275/509 - (54%)
Similarity:	359/509 - (70%)	Gaps:	18/509 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEI---MA 91
            :|::|||..||||||||||.|.::|.||.:||.|||||.| .:|..||.|.|.|.|.||.   |.
  Fly    22 ESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAF-KNKETPNMRFIEALKAHEFADEMM 85

  Fly    92 AFGNADYTQTASQWQMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQ 156
            :..|....     ||.|......||......::|..|:.||||||.||||:.|.:..|.::...|
  Fly    86 SLLNVPLL-----WQQLNAMDYILNKFIDVTMEDEGVQRLLNSGETFDLVLAEMLHMEPMYAFAQ 145

  Fly   157 HFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVH 221
            ||.|..:|.||:|||..|||..|||||:|||||:.|.||::|.|.:|:.|.:|..|..:|:..||
  Fly   146 HFNATLVGFSSFGTDRTIDEAAGNISPISYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVH 210

  Fly   222 LPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLA 286
            ||..|::|.||||.|:|:|:||:|||:|:|||||||||||||||||||||||:|:..|.|  ||.
  Fly   211 LPHMRNVYKKYFPNAKKTLEEVMDSFSLILLGQHFSLSYPRPYLPNMIEVGGMHISHKPK--PLP 273

  Fly   287 KELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFI 351
            :::.:|:|.|..||||||||||:||||||..||..|::|||.:.||||||||||.:|.||.||.|
  Fly   274 EDIKQFIEGSPHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKFEDDDMPGKPANVLI 338

  Fly   352 SKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIW 416
            .||:|||||||||||||||:||||||:.||:||||||||||.|||||:|||||::||:||..|:.
  Fly   339 KKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQRAQRVGFGLGLDLN 403

  Fly   417 SVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDL 481
            ::...:|...||.||::||||.|:...|:.:|||.::|::||:||||||:||.||.|||..||||
  Fly   404 NLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIRHNGAPHLRATSRDL 468

  Fly   482 DFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAEASKLK 535
            :|||.:.|||..:::|:..: |.::::.:.|      .|:...::....|.|||
  Fly   469 NFIQLNSLDTLAVILAVPLL-LALLIVTLSC------KLLGGKKQKCLHADKLK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	254/446 (57%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	255/473 (54%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	261/455 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.880