DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt302K1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	201/540 - (37%)
Similarity:	312/540 - (57%)	Gaps:	45/540 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLIGLIWLFAANADEGVQSS-RILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEP 76
            |::||:      ...|..|. ..|.|....|||.:.......|.|...||.:||::.|...|..|
  Fly     6 LILGLL------CSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIP 64

  Fly    77 NFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMT-TQFLNL---------LTTSILDDAAVKDL 131
            .:..:....:.|:|..       ...:.|..:..| ||  ||         :|..:.:|:..:|.
  Fly    65 GYTDVSVPNVIEVMGG-------DIGALWASIQKTYTQ--NLIDHYQMGFRITRGLFEDSNFQDF 120

  Fly   132 LNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTE 196
            |.|.:.||.:|.|....:|.:||.:||.|..||:::.|..|.|.:::|:.:|.|:.|.::....:
  Fly   121 LKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIMLPFND 185

  Fly   197 QMDFKDRVMNVFEASVMWLHKRIV----HLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFS 257
            .|...:|::||    ....::|::    .||:|..||.::||..::...::..:.:|:|:.||.|
  Fly   186 HMSLYERLLNV----AFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVS 246

  Fly   258 LSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKML 322
            ||:|||:.||||||||:|:.  .|..||.:::..|:.:||.|.||||||||:|:||||||..:.:
  Fly   247 LSFPRPHSPNMIEVGGMHID--GKWNPLPEKIERFINESEHGAIYFSMGSNLKTKDLPPSKVQEI 309

  Fly   323 MQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKP 387
            ::....:.||||||||.|.||.||:||:||.||||.||||||.:..|:||||:|||.||||..||
  Fly   310 LKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKP 374

  Fly   388 ILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKE 452
            ::|||||.||..|:..|:|.|||:..|..::||.|....|:.:.|.|||....|..|..:|||::
  Fly   375 VIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQ 439

  Fly   453 TALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIV--VILIKCLQR 515
            |.:|.||:|.|:|.||:||.:|:.|::.|::.|:|.:|.. |:|.:..|.||||  :.:.|.|::
  Fly   440 TPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLPITIYKLLKK 503

  Fly   516 VFVSLISKIRKNRAEASKLK 535
            :.      ::..|.:::|:|
  Fly   504 LL------LKGERTQSTKVK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	180/469 (38%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	187/486 (38%)
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	189/495 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445603
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.810