DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt49B2

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	184/551 - (33%)
Similarity:	296/551 - (53%)	Gaps:	51/551 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNE- 75
            ||.:.|:::......:|   :||||.|..|.:|.::..:..::||..|||.||.|......|..
  Fly     2 ILFMKLLFVCLLGTGDG---ARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENL 63

  Fly    76 -PNFRVIGAKKIH---EIMAAFGNADYTQTASQWQMLTMT-------TQFLNLLTTSI-LDDAAV 128
             ||:|.|...|..   :|.|..      :|.|...|:.|:       .|.:.:.:|.. |....|
  Fly    64 GPNYREILLPKYDTWADISAMM------KTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEV 122

  Fly   129 KDLLNSGE---KFDLVIMEAVQTEA--LFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNP 188
            ::|:.:.:   ||||:::|....|.  :.|.|....|.||...:|.  .:..::.|.::||||.|
  Fly   123 QELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYA--NYFSQVFGFVNPLSYVP 185

  Fly   189 LLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYF-------PTARKSLDEVLDS 246
            .:..|.|::|...:|:.||..::...:.:.:.:.|.|..:..|:|       ||. |.|::   :
  Fly   186 NVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTV-KQLEQ---N 246

  Fly   247 FALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKS 311
            .:::||..:..|:.|||...|||.|||||:...:   ||.:.:..:::.:|.|.||||:||.::|
  Fly   247 ISVILLNSYMPLTSPRPMSQNMISVGGLHILPPK---PLPEHIKNYLDNAEHGAIYFSLGSQVRS 308

  Fly   312 KDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLL 376
            .|:|....::.:..|||:.|||||||||||||..||||.:.||.||.|||||||||:||.||||.
  Fly   309 ADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLF 373

  Fly   377 STIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQ 441
            ...|::|...|:||:|.::||.:|::..:..||.:..|..:::..:|...:..||.:|.|.|...
  Fly   374 GMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMM 438

  Fly   442 TKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIV 506
            ..|::|||:...|::.|::|..||:.|:||.||..|...|.:.||:.||...:::|||.:.||
  Fly   439 KASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLL-- 501

  Fly   507 VILIKCLQRVFVSLISKIRKNRAEASKLKTQ 537
              .:..:.|.:.|    .|..||:..:.||:
  Fly   502 --TLYAVSRNYKS----FRGIRAQKKEAKTE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	161/479 (34%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	168/495 (34%)
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	177/521 (34%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	164/480 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454710
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D58919at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.900