DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	169/542 - (31%)
Similarity:	263/542 - (48%)	Gaps:	35/542 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GIFSVTGLGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVIN 67
            ||:.:....|.::|           |...:.||.||.....|..|......|.||.||||||||.
  Fly     6 GIYLLLATAICVLG-----------GCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT 59

  Fly    68 TFGSDKNEPNFRVI-------GAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSILDD 125
            ......|..|..||       .::::.:.:.|....|.:........:....:|:.......|.|
  Fly    60 VLKPVVNHKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKD 124

  Fly   126 AAVKDL-LNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPL 189
            ..|:|| ||...|||||:..........|..:...|..|.:::...:..::.|:||...::|.|.
  Fly   125 DRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPS 189

  Fly   190 LLSS--RTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYF---PTARKSLDEVLDSFAL 249
            :..|  :.:.|.|:.|:.....:....:...:....|:| ||.:.|   |. .....|::.:.:|
  Fly   190 ISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKR-LYKELFGDDPN-MPEYSELVKNTSL 252

  Fly   250 MLLGQHFSLSYP-RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKD 313
            :....|.....| ||.:|..||:||  :|.|....||.:.::||:..:..|.|..|:|||:|...
  Fly   253 IFFASHAPSEGPIRPNVPAAIEIGG--IQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSH 315

  Fly   314 LPPSTRKMLMQTFASVPQRVLWKFED-DQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLS 377
            :.|.|...:....:.:.|||:||:|| ::.|.|.||:|.|||.||.|||||||:||||.|.|...
  Fly   316 INPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGG 380

  Fly   378 TIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQT 442
            ..|:.|.|||:|.||:|.||..|.....:.|:||:..:.|:........|.|:||||.|.....:
  Fly   381 ITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVAS 445

  Fly   443 KSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVV 507
            .|.|:||:..:|.|..|:|||||:||.||.||:.....:.||..:.:|.:.|:..:    |:|:|
  Fly   446 FSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVV----LVILV 506

  Fly   508 ILIK-CLQRVFVSLISKIRKNR 528
            :|:| .||.::..:.:|.:|.:
  Fly   507 LLLKLLLQFIYRKIFAKPKKEK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	150/469 (32%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	156/486 (32%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	156/496 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445710
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950