DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	265/540 - (49%)
Similarity:	351/540 - (65%)	Gaps:	41/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKN 74
            :|.||:.|        ...:|::||||:|||||.||||....::||||:|||.||.:|.|...|.
  Fly     6 IGFLLLTL--------PASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKP 62

  Fly    75 EPNFRVIGAKKIHEIMAAFGNADYTQTASQ-------WQMLTMTTQFLNLLTTSILDDAAVKD-L 131
            ..|||.:      .|...|.|  |.:..::       ||......:|...:|..:|.:..|.: |
  Fly    63 VVNFRDV------FIPDVFNN--YKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETL 119

  Fly   132 LNSG-EKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRT 195
            |..| :.|||:|:||::::|.:|...||.|..||||::|||.:||.|:||.|||||.||.....|
  Fly   120 LPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLT 184

  Fly   196 EQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARK--SLDEVLDSFALMLLGQHFSL 258
            ::|.|.:|:.|..:.:|.||:.|.||:..|..:||||||.|.|  .|.::..:|:|:||.|||||
  Fly   185 DRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSL 249

  Fly   259 SYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKML 322
            |:||||:||||||||||:  ..|..||.|:|.||::.| |.||||||:|||:.|||||...:.::
  Fly   250 SFPRPYVPNMIEVGGLHI--SHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLI 312

  Fly   323 MQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKP 387
            ::||||:|||||||||||:||.||.|||||||||||||||||.|||||||||||||||||:.|||
  Fly   313 LKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKP 377

  Fly   388 ILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKE 452
            :||||.||||.|||:||.|.|:||..|..::...||...|:.||..|.:|..|:..|:.:|||..
  Fly   378 VLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPM 442

  Fly   453 TALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVF 517
            :.|:.||||||||||||||.|:|.|.:||.|..:|.||..|:|:.   .:||:|.|:
  Fly   443 SPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLG---GALLLVAII-------- 496

  Fly   518 VSLISKIRKNRAEASKLKTQ 537
            |.::.|:........|||::
  Fly   497 VGVLGKLTDFGNAKKKLKSK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	241/466 (52%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	243/482 (50%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	245/475 (52%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	218/421 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445574
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27372
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.800