DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	163/521 - (31%)
Similarity:	266/521 - (51%)	Gaps:	33/521 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHR--GHNVTVINTF--- 69
            ||.||.|::  ..||         :|.|||...:|.|:|..:.::||...  .|:||:|:..
  Fly     8 LGTLLCGIV--LGAN---------VLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQ 61

  Fly    70 -GSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSI---LDDAAVKD 130
             |.|...|..|.:..:.:.|.....|.:...:......::...|:.:...||::   |.|..|:.
  Fly    62 EGVDAEIPKIRELRIEGLRENWLDMGMSFEAEEMRAQSVMERFTRLIYAGTTNVDILLSDPQVRK 126

  Fly   131 LLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRT 195
            ||.|||||||:|::...::||.||..::|..|:.:|..|.::.::.:.||....|.:|......|
  Fly   127 LLTSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNFLPFT 191

  Fly   196 EQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLD---EVLDSFALMLLGQHFS 257
            |:|:.:.|::|...::...|.....||.||:.:|..:|....|.|.   ::..:.:|.|:..|..
  Fly   192 ERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNLSLALINSHPG 256

  Fly   258 LSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKML 322
            |.|||.|||||:|||||||..... ..|.|.|..|:|.:..||||||:|:::::..||.....::
  Fly   257 LHYPRAYLPNMVEVGGLHLSHLND-DNLPKHLLSFMESAPSGVIYFSLGADVETAQLPQEKLAII 320

  Fly   323 MQTFASVPQ-RVLWKFEDDQLPEK---PDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIY 383
            :..|..:.: ..|.|:|.::...:   |:||.|:.|:||..||.||.||:||:..|.||..|||.
  Fly   321 LDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQLSVWESIS 385

  Fly   384 FGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYA-AAAQTKSKLF 447
            ..||:|.:||..:|.:..:|.::.|..::....|:....|...|::|..|.||. ...|.|.:|.
  Fly   386 GQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQLKERLI 450

  Fly   448 -RDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIK 511
             ||  .|.:.:|:...:.:|...||..|:..:..|:|.:..|:|.. |:||:.|..:|.:..|..
  Fly   451 SRD--STPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVL-LIIAVGFFGILTIPFLAI 512

  Fly   512 C 512
            |
  Fly   513 C 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	146/472 (31%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	149/476 (31%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	152/485 (31%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	129/409 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445633
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I2570
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.900