DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_964007.2	Gene:	Ugt1a1 / 394436	MGIID:	98898	Length:	535	Species:	Mus musculus

Alignment Length:	528	Identity:	150/528 - (28%)
Similarity:	250/528 - (47%)	Gaps:	66/528 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGS-DKNEPNFRV 80
            |:.:|..:|.   .:.|:| |||..| |.::.....:::|..:||.|.||....| ...|.:|..
Mouse    18 LLCVFGPSAS---HAGRLL-VFPMDG-SHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYT 77

  Fly    81 I-------GAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKF 138
            :       ..:.:...:...|...:.|.:.   :|.:...::.:...|.:..|....||::.|
Mouse    78 LRKFPVPFQKENVTATLVELGRTAFNQDSF---LLRVVKIYMKVKRDSSMLLAGCSHLLHNAE-- 137

  Fly   139 DLVIMEAVQTEALF-------GLI--QHFGAETI--------GISSYGTDTHIDELMGNISPLSY 186
            .:..:|....:||.       |.|  |:....|:        .:.|..|...:        ||||
Mouse   138 FMASLEESHFDALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPV--------PLSY 194

  Fly   187 NPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARK------SLDEVLD 245
            .|..||..:::|:|..||.||..|.......|:|        |:.|...|.:      ::.::|.
Mouse   195 VPKSLSFNSDRMNFLQRVKNVLLAVSENFMCRVV--------YSPYGSLATEILQKEVTVQDLLS 251

  Fly   246 SFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNI 309
            ..::.|:...|...||||.:|||:.:||::..||:   ||::|...:|..| |.|::.||:||.:
Mouse   252 PASIWLMRSDFVKDYPRPIMPNMVFIGGINCLQKK---PLSQEFEAYVNASGEHGIVVFSLGSMV 313

  Fly   310 KSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGG 374
              .::|......:.:....:||.|||::...:......|..:.||.||.|:|.||..:.||||.|
Mouse   314 --SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSG 376

  Fly   375 LLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAA 439
            .....|.|..|.|::.:|:|.||..|.:|.:..|.|::.::..:.|.:|...::.:::|.||...
Mouse   377 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 441

  Fly   440 AQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLL 504
            ....|.|.:|:....|:.|::|.|||:|||||.|||.|:.||.:.|:|.||..|.|:||.   |.
Mouse   442 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIV---LT 503

  Fly   505 IVVILIKC 512
            :|.|:.||
Mouse   504 VVFIVFKC 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	130/486 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	140/490 (29%)
Ugt1a1	NP_964007.2	egt	20..507	CDD:223071	146/520 (28%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	147/513 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840308
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690